نتایج جستجو برای: phenformin
تعداد نتایج: 275 فیلتر نتایج به سال:
Practice Pointers The first-line treatments recommended for type 2 diabetes are lifestyle changes and metformin, which is a biguanide antihyperglycemic agent.2 Demonstrated benefits of metformin include lower cardiovascular mortality than other oral diabetes medications3 and a reduced risk of death or myocardial infarction in overweight patients with type 2 diabetes.4 However, because an earlie...
Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p<0.001) in blood glucose levels and was also found effective in restoring the blood lipid...
SYNOPSIS The fibrinolytic response of 30 diabetic patients and 35 non-diabetics to 0-5 mg. subcutaneous adrenaline was measured, using the dilute clot lysis test. With the exception of two patients out of six who were taking phenformin, who had a depressed response, the diabetics showed a similar increase in fibrinolytic activity to the non-diabetics. The diabetics in this series did not tend t...
We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine's known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α-enolase ...
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