In this study, solvent-free and phase transfer catalysis conditions coupled with microwave irradiation and their advantages in synthesis of N-alkylation of primary anilines were reported. In this way two different microwave processing techniques were compared in terms of reaction yields. Consequently, microwave irradiation significantly reduced reaction times compared to traditional heating met...

3,4-dihydropyridin-2-ones are of considerable importance due to the large number these core structures exhibiting a diverse array biological and pharmacological activities. The Michael-type addition 1,3-dithiane-2-carbothioates α,β-unsaturated N-tosyl imines, followed by intramolecular annulation driven sulfur leaving group, provides practical reaction cascade for synthesis variety substituted ...

Considerable attention has been focused on proton transfer through intervening water molecules in complex macromolecules of biological interest, such as bacteriorhodopsin, cytochrome c oxidase, and many others. Proton transfer in catalysis by carbonic anhydrase provides a useful model for the study of the properties of such proton translocations. High-resolution X-ray crystallography in combina...