Precipitons are molecular phase tags for chemical separations. They can be switched from a high-solubility to a low-solubility state to facilitate product, reagent, or catalyst isolation. This paper presents the first photoactivated precipiton and demonstrates that this precipiton is an efficient amine scavenging agent in solution-phase syntheses of amides, ureas, and imines. This approach to a...

Purpose: Hydrotropes increases the solubility of organics in water. Objective of present investigation was to enhance the solubility of griseofulvin using the technique of hydrotropic solubilization technique and convert them into suitable oral liquid dosage form (suspension) useful for enhancement of bioavailability. Methods: 0.5M, 1M, 2M of the hydrotropes (tri sodium citrate, urea, sodium ac...

Pioglitazone is an anti-diabetic drug in high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes) which was belongs to poor aqueous solubility and bioavailable drug. By using β Cyclodextrin, the solubility and dissolution rate of Pioglitazone HCL can be enhanced and it was evaluated by synthesizing it into solid inclusion complexes in different ratio of drug: β cyclode...

Amelogenins are a group of extracellular enamel matrix proteins which are believed to be involved in the regulation of the size and habits of forming enamel crystals. The aim of this study was to compare the solubility properties of several amelogenins at various pH (from 4.0 to 9.0) at constant ionic strength (IS), and to examine the influence of buffer composition, IS, and divalent metal ions...

introduction: solubility of mineral trioxide aggregate (mta) is an important characteristic that affects other properties such as microleakage and biocompatibility. distilled water (dw) has previously been used for solubility tests. this experimental study compared the solubility of mta in dw, synthetic tissue fluid (stf) and new simulated plasma (sp). methods and materials: in this study, 36 s...

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

In any lipid bilayer membrane, there is an upper limit on the cholesterol concentration that can be accommodated within the bilayer structure; excess cholesterol will precipitate as crystals of pure cholesterol monohydrate. This cholesterol solubility limit is a well-defined quantity. It is a first-order phase boundary in the phospholipid/cholesterol phase diagram. There are many different solu...

The isothermal section of the Ce-Mg-Zn system at 300 °C was experimentally established in the full composition range via diffusion multiple/couples and key alloys. Annealed key alloys were used to confirm the phase equilibria obtained by diffusion multiple/couples and to determine the solid solubility ranges. Spot analysis was carried out, using wavelength dispersive X-ray spectroscopy (WDS), t...

1. In vitro assays provide a sensitive and economic tool to evaluate dietary effects, but have limitations. In this study, the effect of phytase supplementation on solubility, and presumed availability, of calcium (Ca) and phosphorus (P) in soybean meal (SBM) and rapeseed meal (RSM) based diets was evaluated both in situ and by a 2-step in vitro digestion assay that simulated the gastric and sm...