Pharmacogenetics blends important components of the disciplines of genetics and pharmacology, and aims to describe the influence of inheritance on variable drug response. This review provides an overview of the history and current status of pharmacogenetics. The role of genetics in variable drug response is now firmly established. To apply this information to the clinical setting, more sophisti...

The core hypothesis underlying pharmacogenetics is that genetic factors play a significant role in the well-recognized differences between individuals in response to medication and susceptibility to adverse effects. If these genetic factors can be identified and understood, they may serve as predictors to guide clinicians in tailoring medication to the individual patient. Recent developments in...

OBJECTIVE To study the performance of pharmacogenetics-based warfarin dosing algorithms in the initial and the stable warfarin treatment phases in a cohort of Han-Chinese patients undertaking mechanic heart valve replacement. METHODS We searched PubMed, Chinese National Knowledge Infrastructure and Wanfang databases for selecting pharmacogenetics-based warfarin dosing models. Patients with me...

A phenotype describes a group of patients who present with similar clinically observable characteristics. An endotype is subgroup share the same pathophysiologic processes that lead to disease presentation. Asthma complex chronic disorder consists many identifiable phenotypes and two generally accepted endotypes. Understanding characteristics underlying inflammation requires lung biopsies or br...

A key challenge for pharmacogenetics is the creation of databases to store, analyse and disseminate important datasets in order to catalyse research and training. Most successful databases have a limited scope: Genbank contains DNA sequences [1]; the Protein Data Bank contains the three-dimensional coordinates of macromolecules [2]; the Online Mendelian Inheritance in Man contains a record of h...

The hypothesis of each individual being special and different leading to heterogenity of diseases sets the ground for the concept of personalized medicine. Personalized psychiatry follows the principles of personalized medicine. A constituent part of an individually adapted approach towards the psychiatric patient presents itself thorough personalized psychiatry. The development of pharmacogeno...