1Department of Translational Medical Sciences, Federico II University and R&D, Federico II University Hospital, Naples, Italy 2Roessingh Research and Development, Telemedicine Group, Enschede, Netherlands 3Telemedicine Group, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, Enschede, Netherlands 4Centre for Gerontology and Rehabilitation, St. Finbarr’s ...

EGFR: Epidermal Growth Factor Receptor; EGFR M+: Epidermal Growth Factor Receptor Activating Mutation Positive; EMA: European Medicines Agency; ICER: Incremental Cost Effectiveness Ratio; HTA: Health Technology Assessment; NCPE: National Centre for Pharmacoeconomics; NICE: National Institute of Health and Care Excellence; NSCLC: Non Small Cell Lung Cancer; OS: Overall Survival; PEA: Pharmaco-Ec...

The HSE has asked the National Centre for Pharmacoeconomics (NCPE) to evaluate the manufacturer’s (Bayer) economic dossier on the cost effectiveness of radium223. The NCPE uses a decision framework to systematically assess whether a technology is cost effective. This includes clinical effectiveness and health related quality of life benefits that the new treatment may provide and whether the co...

1Department of Translational Medical Sciences, Federico II University and R&D, Federico II University Hospital, Italy 2Roessingh Research and Development, Telemedicine Group, Enschede, Netherlands 3University of Twente, Faculty of Electrical Engineering, Mathematics and Computer Science, Telemedicine Group, Enschede, Netherlands 4Centre for Gerontology and Rehabilitation, St. Finbarr’s Hospital...

Life expectancy has increased over the last century as it had never been before. This is the result of a combination of many favorable variables such as level of education, improved socio-economic environment and development of medicine. However, new improvements demand heavy investment. Thus, the incorporation of medical technology became a health and economic issue. The pharmacoeconomic knowl...

OBJECTIVES The first aim of this workshop was to define pharmacoeconomic concepts and terminology. Pharmacoeconomics can be defined as the branch of economics that uses cost-benefit, cost-effectiveness, cost-minimization, cost-of-illness and cost-utility analyses to compare pharmaceutical products and treatment strategies. Economic evaluations provide healthcare decision-makers with valuable in...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 649 1. Frequentist and Bayesian Paradigms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 650 1.1 Contrasts: Parameter Estimates, Confidence Intervals, Hypothesis Testin...

The treatment of acquired haemophilia is characteristically exceedingly expensive and thus a cost-benefit analysis of the several available treatment strategies is urgently needed. To address this issue, decision-analysis techniques were used to construct a cost-minimization model to compare the cost of treatment with porcine factor VIII (pFVIII), human FVIII (hFVIII) or an activated prothrombi...