نتایج جستجو برای: pharmaceutic adjuvants

تعداد نتایج: 6128  

2017
Andri Vasou Nazife Sultanoglu Stephen Goodbourn Richard E. Randall Leondios G. Kostrikis

Modern vaccinology has increasingly focused on non-living vaccines, which are more stable than live-attenuated vaccines but often show limited immunogenicity. Immunostimulatory substances, known as adjuvants, are traditionally used to increase the magnitude of protective adaptive immunity in response to a pathogen-associated antigen. Recently developed adjuvants often include substances that st...

2014
Angela Berzi Norbert Varga Sara Sattin Patrizio Antonazzo Mara Biasin Irene Cetin Daria Trabattoni Anna Bernardi Mario Clerici

The development of new and effective adjuvants may play a fundamental role in improving HIV vaccine efficacy. New classes of vaccine adjuvants activate innate immunity receptors, notably toll like receptors (TLRs). Adjuvants targeting the C-Type lectin receptor DC-SIGN may be alternative or complementary to adjuvants based on TRL activation. Herein we evaluate the ability of the glycomimetic DC...

2017
Jun Liu Mario Ostrowski

Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit a durable and potent memory response from B cells, CD8+ T cells, and NK cells but avoid overstimulation of HIV-1 susceptible CD4+ T cells, especially at genital and rectal mucosa, the main...

Journal: :Contribuciones a las ciencias sociales 2023

Eugenol (C10H12O2) presents various therapeutic properties. Due to this fact, it arises interest into the pharmaceutic industry and has a commercial value. However, there is still low offer of product in market. The aim work was evaluate concentration essential oil from dried leaves O. gratissimum L., determine whether species bares promising characteristics as source eugenol. Fresh Ocimum L. w...

2014
Ali Neamati Mohammad Hossein Boskabady Abass Tabatabaei Saleh Mohaghegh Hazrati

BACKGROUND Anti-inflammatory effect of natural adjuvants has been reported. Lung inflammation is the most characterized pathological feature in asthma. OBJECTIVES The effects of three natural adjuvants (PC, G2, and G2F registered as a patent in the Iranian Patent Office) on sensitized guinea pigs lungs were examined in the present study. MATERIALS AND METHODS LUNG PATHOLOGICAL CHANGES WERE ...

2017
Valeria Quattrocchi Ivana Soria Cecilia Ana Langellotti Victoria Gnazzo Mariela Gammella Dadin P. Moore Patricia I. Zamorano

Bovine herpesvirus-1 (BoHV-1) is the causative agent of bovine infectious rhinotracheitis, an important disease worldwide. Although conventional BoHV-1 vaccines, including those based on the use of modified live virus and also inactivated vaccines, are currently used in many countries, they have several disadvantages. DNA vaccines have emerged as an attractive approach since they have the poten...

Journal: :Immunology and cell biology 2004
Nikolai Petrovsky Julio César Aguilar

The problem with pure recombinant or synthetic antigens used in modern day vaccines is that they are generally far less immunogenic than older style live or killed whole organism vaccines. This has created a major need for improved and more powerful adjuvants for use in these vaccines. With few exceptions, alum remains the sole adjuvant approved for human use in the majority of countries worldw...

2016
Annalisa Ciabattini Elena Pettini Fabio Fiorino Gabiria Pastore Peter Andersen Gianni Pozzi Donata Medaglini

Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Here early biomarkers of adjuvanticity after primary immunization were investigated using four different adjuvants combined with the chimeric tuberculosis vaccine antigen H56. C57BL/6 mice were immunized by the subcutaneous route with different vaccine formulations, and the modulation of...

Journal: :Immunologic research 2013
S Cerpa-Cruz P Paredes-Casillas E Landeros Navarro A G Bernard-Medina G Martínez-Bonilla S Gutiérrez-Ureña

A traditional infectious disease vaccine is a preparation of live attenuated, inactivated or killed pathogen that stimulates immunity. Vaccine immunologic adjuvants are compounds incorporated into vaccines to enhance immunogenicity. Adjuvants have recently been implicated in the new syndrome named ASIA autoimmune/inflammatory syndrome induced by adjuvants. The objective describes the frequencie...

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