نتایج جستجو برای: phage vaccine

تعداد نتایج: 127647  

2009
Franci Smrekar Aleš Podgornik Mateja Ciringer Lidija Urbas

Bacteriophages, viruses that infect bacteria, were discovered at the beginning of the twentieth century. Today, phages are being used as antibacterial agents, in phage display screening, in the development of phage delivery vaccines, as targeted gene therapy delivery systems, and for specific bacteria typing. In order to use phages in these applications, they are commonly purified by liquid chr...

2012
Victor Seguritan Nelson Alves Michael Arnoult Amy Raymond Don Lorimer Alex B. Burgin Peter Salamon Anca M. Segall

Phages play critical roles in the survival and pathogenicity of their hosts, via lysogenic conversion factors, and in nutrient redistribution, via cell lysis. Analyses of phage- and viral-encoded genes in environmental samples provide insights into the physiological impact of viruses on microbial communities and human health. However, phage ORFs are extremely diverse of which over 70% of them a...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Elena Del Tordello Olga Danilchanka Andrew J McCluskey John J Mekalanos

The bacterial type 6 secretion system (T6SS) is a dynamic apparatus that translocates proteins between cells by a mechanism analogous to phage tail contraction. T6SS sheaths are cytoplasmic tubular structures composed of stable VipA-VipB (named for ClpV-interacting protein A and B) heterodimers. Here, the structure of the VipA/B sheath was exploited to generate immunogenic multivalent particles...

2013
Joanna Houghton Teresa Cortes Olga Schubert Graham Rose Angela Rodgers Megan De Ste Croix Rudolf Aebersold Douglas B. Young Kristine B. Arnvig

Enhanced transcription of the Rv2660c locus in response to starvation of Mycobacterium tuberculosis H37Rv encouraged addition of the predicted Rv2660c protein to an improved vaccine formulation. Using strand-specific RNA sequencing, we show that the up-regulated transcript is in fact a small RNA encoded on the opposite strand to the annotated Rv2660c. The transcript originates within a prophage...

Journal: :Journal of immunology 2007
Carla Lo Passo Angela Romeo Ida Pernice Paolo Donato Angelina Midiri Giuseppe Mancuso Milena Arigò Carmelo Biondo Roberta Galbo Salvatore Papasergi Franco Felici Giuseppe Teti Concetta Beninati

Neisseria meningitidis serogroup B (MenB) is a leading cause of sepsis and meningitis in children. No vaccine is available for the prevention of these infections because the group B capsular polysaccharide (CP) (MenB CP) is unable to stimulate an immune response, due to its similarity with human polysialic acid. Because the MenB CP bears both human cross-reactive and non-cross-reactive determin...

Journal: :Nature microbiology 2021

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii established that the bacterial capsule is receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible biosynthesis, resulting loss disruption phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam an...

Journal: :acta medica iranica 0
p. adibfar

33 stools from 518 patients suspected of having cholera were examined. from 174 of these patients vibrio ei tor was isolated. po of these strains belonged to phage type iv, 53 to phage type v and one strain was untypable. it is suggested that these strains originated from two different sources.

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