BACKGROUND S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Skp2 has been demonstrated to display an oncogenic function since its overexpression has been observed in m...

The randomized, double-blinded Royal Marsden Tamoxifen Breast Cancer Prevention Trial in healthy high-risk women started in 1986 and is still blinded. Eligible participants (n = 2,471) were randomly assigned to tamoxifen (20 mg/d) or placebo for 8 years. Analysis in 2006 showed a 30% risk reduction of estrogen receptor (ER)-positive invasive breast cancer mostly in the posttreatment period. Bio...

This paper addresses the expression of the epidermal growth factor (EGF) gene by human breast tumor biopsy samples. Northern analysis was used to demonstrate the presence of an approximately 5-kilobase mRNA which specifically hybridized with radiolabeled human EGF complementary DNA in some human breast tumor biopsy samples. Quantitation of EGF mRNA in 60 human breast tumor biopsies using the RN...

Endometriosis is characterized by the presence of endometrial-like tissue located outside the uterine cavity. Recent evidence suggests that endometriosis may be an epigenetic disease, as well as an estrogen-dependent disease. Based on the unique steroid hormone receptor expression profile observed in endometriotic lesions as compared to eutopic endometrium, the present study aimed to gain furth...

The aim of this paper is to introduce and characterize pgrαregular spaces and pgrαnormal spaces via the concept of pgrαclosed sets. It also focuses on some of its basic properties and discusses on separation axioms between pgr-T0 and pgr-T1. An attempt has been made to make a comparative study with other usual separation axioms. Mathematics Subject Classification: 54C10, 54C08, 54C05

AIMS AND BACKGROUND Based on estrogen receptor (ER), progesterone receptor (PgR) and Her2/neu (HER2) expression, four breast cancer subtypes have been distinguished: luminal A (ER and/or PgR/HER2-, Ki67 <14%), luminal B (ER and/or PgR/HER2-, Ki67 ≥14% or ER and/or PgR/HER2), triple-negative (ER-/PgR-/HER2-), and HER2 (ER-/PgR-/HER2). Our aim was to evaluate the prognosis of these phenotypes in ...

Dean E. Riechers Corresponding author. Department of Crop Sciences, University of Illinois, Urbana, IL 61801; [email protected] Two studies investigated off-target exposure of soybean to plant growth regulator (PGR) herbicides and determined if simultaneous exposure to PGR herbicides and labeled soybean herbicides increase PGR injury. The PGR herbicides, 2,4-D, clopyralid, and dicamba, as well ...

BACKGROUND Limited data are available on the prognostic value of changes in the biological features of residual tumours following neoadjuvant therapies in breast cancer patients. PATIENTS AND METHODS We collected information through the institutional clinical database on all consecutive breast cancer patients treated with neoadjuvant chemotherapy at the European Institute of Oncology (IEO), M...

The prognosis of breast cancer in pre-menopausal women is very variable and dependent on the interactions several biological factors. androgen receptor (AR) could be among prognostic variables related to survival although data scarce. aim study was examine relationship between expression outcomes estrogen (ER)-positive invasive carcinoma patients. We assessed AR ER-positive carcinomas correlate...

Monitoring of the indicator Sustainable Development Goal (SDG) 11.3.1 is important for understanding coordination between land consumption rate (LCR) and population growth (PGR). However, spatiotemporal SDG changes at urban agglomeration (UA) level, relationship LCR PGR in prefecture-level cities from different UAs remains unclear. In this study, we monitored Yangtze River Economic Belt (YREB) ...