نتایج جستجو برای: pgi

تعداد نتایج: 1108  

Journal: :Journal of immunology 2007
Weisong Zhou Koichi Hashimoto Kasia Goleniewska Jamye F O'Neal Shaoquan Ji Timothy S Blackwell Garret A Fitzgerald Karine M Egan Mark W Geraci R Stokes Peebles

Signaling through the PGI(2) receptor (IP) has been shown to inhibit inflammatory responses in mouse models of respiratory syncytial viral infection and OVA-induced allergic responses. However, little is known about the cell types that mediate the anti-inflammatory function of PGI(2.) In this study, we determined that PGI(2) analogs modulate dendritic cell (DC) cytokine production, maturation, ...

2013
Alice Toniolo Carola Buccellati Christian Pinna Rosa Maria Gaion Angelo Sala Chiara Bolego

This study aimed at evaluating the relative contribution of endothelial cyclooxygenase-1 and -2 (COX-1 and COX-2) to prostacyclin (PGI(2)) production in the presence of mild oxidative stress resulting from autooxidation of polyphenols such as (-)-epigallocatechin 3-gallate (EGCG), using both endothelial cells in culture and isolated blood vessels. EGCG treatment resulted in an increase in hydro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1982
D B Ullrey A Franchi J Pouyssegur H M Kalckar

Down-regulation ("curb") of hexose transport in Chinese hamster lung fibroblasts has been studied in a metabolic mutant highly defective in phosphoglucose isomerase (PGI; glucosephosphate isomerase; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9). In the parental strain (PGI+) glucose as well as glucosamine and mannose were able to elicit a curb of the hexose transport system. In the PGI mut...

Journal: :Journal of virology 2004
Koichi Hashimoto Barney S Graham Mark W Geraci Garret A FitzGerald Karine Egan Weisong Zhou Kasia Goleniewska Jamye F O'Neal Jason D Morrow Russell K Durbin Peter F Wright Robert D Collins Tatsuo Suzutani R Stokes Peebles

The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I(2) (PGI(2)). Mice that overexpress PGI(2) synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to ...

Journal: :Proceedings. Biological sciences 2009
Marjo Saastamoinen Suvi Ikonen Ilkka Hanski

Individuals with a particular variant of the gene phosphoglucose isomerase (Pgi) have been shown to have superior dispersal capacity and fecundity in the Glanville fritillary butterfly (Melitaea cinxia), raising questions about the mechanisms that maintain polymorphism in this gene in the field. Here, we investigate how variation in the Pgi genotype affects female and male life history under co...

2012
Sung Ho Lee Pil Sang Song Wook Sung Kim Kwang Bo Park Seung-Hyuk Choi

The incidence of peri-stent graft infection (PGI) following thoracic endovascular aortic repair (TEVAR) is low, but the associated mortality rates are extremely high. The diagnosis of this complication can be difficult due to nonspecific symptoms. Here, we report a case of PGI combined with an aorto-esophageal fistula (AEF) diagnosed by computed tomography (CT) and positron emission tomography ...

Journal: :Circulation research 2008
Tongrong He Tong Lu Livius V d'Uscio Chen-Fuh Lam Hon-Chi Lee Zvonimir S Katusic

The role of prostaglandin production in the control of regenerative function of endothelial progenitor cells (EPCs) has not been studied. We hypothesized that activation of cyclooxygenase (COX) enzymatic activity and the subsequent production of prostacyclin (PGI(2)) is an important mechanism responsible for the regenerative function of EPCs. In the present study, we detected high levels of COX...

Journal: :The Journal of rheumatology 2013
Sofia de Achaval Michael A Kallen Maureen D Mayes Maria A Lopez-Olivo Maria E Suarez-Almazor

OBJECTIVE To evaluate the content and construct validity of an individualized patient-reported instrument, the Patient-generated Index (PGI), in patients with systemic sclerosis (SSc), and to compare its performance to that of other instruments and to the Patient-reported Outcomes Measurement Information System (PROMIS) framework. METHODS Patients identified the 5 most important life areas af...

2017
David Shaker Alexander J Lindgren Gwenda Chapman

Introduction Our study aimed to assess the impact of managed complications of tension-free vaginal tape (TVT) on the patients' assessment of the results as measured by Patient Global Impression of Improvement (PGI-I). Materials and methods This was a retrospective study, supplemented with a telephone interview, comparing patients who had complications of TVT procedures with those where no com...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
E P Dahlhoff N E Rank

Allele frequency variation at the phosphoglucose isomerase (PGI) locus in Californian populations of the beetle Chrysomela aeneicollis suggests that PGI may be undergoing natural selection. We quantified (i) apparent Michaelis-Menten constant (K(m)) of fructose 6-phosphate at different temperatures and (ii) thermal stability for three common PGI genotypes (1-1, 1-4, and 4-4). We also measured a...

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