Eliminating from physiologic circulation a significant amount of unnecessary perfluorocarbons (PFC) is advantageous since little is known about long-term effects of PFC in the circulatory system. The basic circuitry, cell-washer, mechanical manipulations, and overall concept revealed that a significant amount of PFC can be retrieved and estimated in volume and compared to initial volumes. A met...

The concept, structures, and algorithms of principal feature classification (PFC) are presented in this paper. PFC is intended to solve complex classification problems with large data sets. A PFC network is designed by sequentially finding principal features and removing training data which has already been correctly classified. PFC combines advantages of statistical pattern recognition, decisi...

We investigated working memory in patients with focal brain damage involving subregions of the prefrontal cortex (PFC). Lesions in the dorsal portion of lateral PFC or the ventromedial portion of orbital PFC did not impair performance in tasks that required maintenance and monitoring of object or spatial information. Larger lesions involving both ventral and dorsal parts of the lateral PFC impa...

It has been shown that dopamine (DA) modulates memory 0elds of dorsolateral prefrontal cortex (PFC) neurons. The DAergic neurons which project to the PFC are localized in the midbrain. We here developed a computational model network which includes the PFC circuit and the mesencephalic DA unit to analyze the circuit property of the cortico-mesocortical system. In our computer simulation, the cor...

We present a model of visual working memory in ventral prefrontal cortex. Activation in ventral PFC consists of reverberating activity. Representations in ventral PFC are conjunctions of location and (partial) identity representations. With many objects, representations in ventral PFC interfere, which results in loss of information. Therefore, the number of objects in working memory is limited....

Modulation of the cyclical response in rabbits to aggregated human gamma globulin (AHuIgG) was investigated in order to study some of the parameters involved in self-regulation of the immune response. Several mitogens (lipopolysaccharide [LPS], phytohemagglutinin [PHA], and concanavalin A [Con A]), when injected simultaneously with antigen, have been shown to modulate the normal splenic plaque-...

During goal-directed behavior, the prefrontal cortex (PFC) exerts top-down control over numerous cortical and subcortical regions. PFC dysfunction has been linked to many disorders that involve deficits in cognitive performance, attention, motivation, and/or impulse control. A common theme among these disorders is that neuromodulation of the PFC is disrupted. Anatomically, the PFC is reciprocal...

Power-factor-correction (PFC) power supplies are required to provide high input power factor and tight output voltage regulation. The usual configuration takes a two-stage cascade structure, consisting of a PFC preregulator and a dc/dc converter. Previous studies of the dynamical behaviour mainly focused on the boost PFC preregulator, assuming that it is being terminated by a resistive load. Ho...

Several decades of patient, functional imaging and neurophysiological studies have supported a model in which the lateral prefrontal cortex (PFC) acts to suppress unwanted saccades by inhibiting activity in the oculomotor system. However, recent results from combined PFC deactivation and neural recordings of the superior colliculus in monkeys demonstrate that the primary influence of the PFC on...

Previous research has demonstrated that hypomania is associated with approach motivation and activity in the left prefrontal cortex (PFC). Other research has linked left motor cortex excitability to approach motivation, suggesting the existence of connections between the motor cortex and PFC. The present research extends this work using unilateral hand contractions to manipulate contralateral c...