For a systematic review of postoperative analgesic efficacy and adverse effects of single doses, injected or oral, of pethidine and ketorolac compared with placebo, we sought published randomized studies in moderate to severe postoperative pain. Information on summed pain intensity or pain relief outcomes over 4-6 h was extracted and converted to dichotomous information to produce the number of...

Vaso-occlusive crises (VOC) is common and opioids are the treatment of choice.This study compared parenteral pethidine morphine in elimination/reduction pain acute VOC to tolerable levels. This open-label randomized intravenous 5 mg 4 hourly intramuscular 75 hourly. Eighty-two consenting adult sickle cell disease participants were recruited from Korle-Bu Polyclinic. (Forty-one each arm). There ...

Objective: To assess the efficacy of Pethidine versus Tramadol in controlling shivering after spinal anaesthesia patients selected for lower limb surgery.
 Study Design: Quasi-experimental study
 Place and Duration Study: Department Anaesthesiology, Combined Military Hospital, Multan Pakistan, from Jun 2019 to Dec 2020.
 Methodology: Seventy-four individuals (aged: 18 65 years) t...

Patient-controlled analgesia (PCA) with i.v. opioids is prescribed increasingly. We report three cases of norpethidine toxicity in patients receiving pethidine by PCA.

Background: Peripartum anesthesia may consist of parenteral opioids and/or regional analgesia. There is only limited data in the literature comparing both methods in daily obstetric practice. This observational study investigated the opioids pethidine and meptazinol as well as regional analgesics with regard to their administration, efficacy, side effects and subjective maternal satisfaction wi...

introduction: prolonged labor can lead to maternal and neonatal complications. the purpose of this study was to investigate the effect of pethidine on the duration of active labor in nulli-parous women. materials and methods: in a randomized clinical 90 nulliparous women with uncomplicated singleton pregnancies at term were randomly assigned into two groups. the first group received 50 mg pethi...