L-glutamate and its receptors (GluRs) play a key role in excitatory neurotransmission within the mammalian central nervous system (CNS). Impaired regulation of GluRs has also been implicated in various neurological disorders. GluRs are classified into two major groups: ionotropic GluRs (iGluRs), which are ligand-gated ion channels, and metabotropic GluRs (mGluRs), which are coupled to heterotri...

Recent advances in SPECT technology including cadmium-zinc-telluride (CZT) semiconductor detector material may pave the way for absolute myocardial blood flow (MBF) measurements by SPECT. The aim of the present study was to compare K1 uptake rate constants as surrogates of absolute MBF and myocardial flow reserve index (MFRi) in humans as assessed with a CZT SPECT camera versus PET. METHODS A...

gliomas account for almost 80% of primary malignant brain tumors in adults. magnetic resonance imaging (mri) is still the gold standard for diagnosis of brain tumors and brain 99mtc-tetrofosmin single photon emission computed tomography (99mtc-tetrofosmin-spect) has been established as a useful tool for their evaluation. fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography/comput...

After reading Part IV of this series of nuclear cardiology articles, the reader should be able to describe: (a) the differences between SPECT and PET techniques; (b) the various radiopharmaceuticals and imaging protocols used for detecting viability with SPECT; (c) the different radiopharmaceuticals and imaging protocols used for detecting viability with PET; and (d) the imaging patterns observ...

We compare analytically techniques for multiplephoton coincidence imaging in terms of spatial resolution, detector efficiency (or simply efficiency), and system sensitivity for a spherical water phantom (or simply sensitivity). One analysis consists of comparing photon-photon coincidence single-photon-emission computerized tomography (PP-SPECT) with angularly unconstrained, electronically colli...

This review sets out to discuss the foremost applications of artificial intelligence (AI), particularly deep learning (DL) algorithms, in single-photon emission computed tomography (SPECT) and positron (PET) imaging. To this end, underlying limitations/challenges these imaging modalities are briefly discussed followed by a description AI-based solutions proposed address challenges. will focus o...

PURPOSE To date there have been only scattered case reports comparing the nuclear medicine characteristics of gangliogliomas with their histologic grade. We sought to determine the relative usefulness of nuclear medicine scanning, CT, and MR imaging in predicting the histologic grade of these tumors. METHODS Eleven cases of pathologically proved ganglioglioma were analyzed retrospectively. Pr...

intensity that can reflect microvascular injuries and thus explain dementia or cognitive impairment. Readers are also presented with the cerebrovascular risk factors for Alzheimer disease, as well as the tantalizing topic of the differential contribution of vascular and degenerative processes to a patient’s dementia. Readers will be led to ponder the sensitivity of this topic because of the fuz...

We studied the radioisotope iodine-123-iodoamphetamine ([123I]IMP) and its performance in single-photon emission computed tomographic (SPECT) studies of cerebral blood flow (CBF). In seven normal volunteers, IMP/SPECT CBF measurements were calculated using a two-compartment model and were compared with the results of CBF measurements utilizing (O15)-H2O and positron emission tomography (PET). C...

Cerebral pain mechanisms are poorly understood when compared with the peripheral nervous system and spinal cord. Reasons for this have included a lack of suitable examination techniques, especially in humans. The recent availability of a number of relatively non-invasive methods that can produce images of functional brain activity has renewed interest in this field. Three of these techniques wi...