The announcement of the 1978 Lasker Award for Basic Medical Research has created two controversies. No one argues with the choice of the three winners-Solomon H. Snyder (Johns Hopkins University), John Hughes (Imperial College of Science and Technology. London), and Hans Kosterlitz (University of Aberdeen) —who were honored for the discovery of opiate receptors and enkephalins, opiate-like subs...

ABSTRAK
 Sekitar 80-90% pasien cystic fibrosis akan mengalami pancreatic insuffiency. Keadaan ini menyebabkan terjadinya malabsorpsi lemak dan protein berpengaruh pada status nutrisi dari pasien. Terapi insufficiency adalah dengan pemberian enzyme replacement therapy (PERT) untuk meningkatkan absorpsi juga fibrosis. Tujuan kajian sistematis mengetahui efikasi keamanan terapi PERT yang sehi...

The cellular composition of heterogeneous samples can be predicted using an expression deconvolution algorithm to decompose their gene expression profiles based on pre-defined, reference gene expression profiles of the constituent populations in these samples. However, the expression profiles of the actual constituent populations are often perturbed from those of the reference profiles due to g...

Of the mutationally defined rhythm genes in Drosophila melanogaster, period (per) has been studied the most. We have molecularly characterized three older per mutants-perT, perClk, and per04-along with a novel long-period one (perSLIH). Each mutant is the result of a single nucleotide change. perT, perClk, and perSLIH are accounted for by amino acid substitutions; per04 is altered at a splice s...

Ad Ad Addr dr dres es ess s s fo fo for r r Co Co Corr rr rres es espo po pond nd nden en ence ce ce: : : Ra Rach chel el L Lam ampe pert rt, MD MD

Ad Ad Addr dr dres es ess s s fo fo for r r Co Co Corr rr rres es espo po pond nd nden en ence ce ce: : : Ra Rach chel el L Lam ampe pert rt, MD MD

In a stochastic interdiction game a proliferator aims to minimize the expected duration of a nuclear weapons development project, while an interdictor endeavors to maximize the project duration by delaying some of the project tasks. We formulate static and dynamic versions of the interdictor’s decision problem where the interdiction plan is either pre-committed or adapts to new information reve...