BACKGROUND Clara cell protein (CC16) is ascribed a protective and anti-inflammatory role in airway inflammation. Lower levels have been observed in asthmatic subjects as well as in subjects with intermittent allergic rhinitis than in healthy controls. Nasal nitric oxide (nNO) is present in high concentrations in the upper airways, and considered a biomarker with beneficial effects, due to inhib...

Deficiency of Vitamin D in the Indian subcontinent is emerging as a major noninfectious epidemic. To correlate vitamin D deficient children with the asthma and allergic rhinitis classification and pulmonary function tests. We studied 66 children with asthma and allergic rhinitis between 6 to 12 years of whom 33 cases were administered Vitamin D and 33 controls who were not given Vitamin D. The ...

The drug treatment for allergic rhinitis comprises the use of intranasal corticosteroids, as well as histamine and cysteinyl leukotriene antagonists. Current guidelines advocate the use of histamine receptor antagonists for the treatment of intermittent or persistent allergic rhinitis, particularly due to seasonal pollen exposure, as these drugs have a fast onset of action (1). These drugs tend...

BACKGROUND Nasal inflammation in allergic rhinitis enhances bronchial Th2 driven inflammation and development of asthma. We assessed bronchial inflammation induced by natural allergen exposure during pollen season in patients with pollinosis with or without asthma to show the intensity of inflammation in asthma and rhinitis and possible persistence of inflammation in periods without allergen ex...

Background Clinical trials with the newer 2nd generation antihistamines in children under the age of 12 years have been performed previously but further studies are needed in order to show efficacy and safety in the most unfavourable clinical conditions such as persistent allergic rhinitis (PER). Rupatadine oral solution was developed for children with allergic rhinitis in view of its rapid ons...

BACKGROUND Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS A cross-sectional observational study of indiv...

OBJECTIVE To compare active acupuncture with sham acupuncture for the treatment of persistent allergic rhinitis among children. METHODS Subjects with persistent allergic rhinitis were recruited from the pediatric outpatient clinic. They were randomized to receive either active acupuncture or sham acupuncture. Main outcome measures included daily rhinitis scores, symptom-free days, visual anal...

The association between the upper and lower airways has been recognised for almost 2000 years. Epidemiological data suggest that most asthma patients also suffer from allergic rhinitis, and that both diseases share similar trigger factors and pathophysiology. This IPCRG Guideline on the management of rhinitis in primary care is fully consistent with the ARIA guidelines. It highlights the treatm...