نتایج جستجو برای: perivascular epithelioid cell neoplasms
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PEComas are an uncommon group of mesenchymal neoplasms that exhibit perivascular epithelioid cell differentiation. The term PEComa includes a collection of different subcategories, such as lymphangioleimyomatosis, clear cell tumor of the lung, and angiomyolipoma (AML) which is the topic of discussion in this article. The main problem concerning the diagnosis of hepatic AML is the wide non-speci...
Address: 1Department of Pathology, Yale University School of Medicine, New Haven, CT, USA, 2Department of Laboratory Medicine Yale University School of Medicine, New Haven, CT, USA, 3Department of Genetics, Yale University School of Medicine, New Haven, CT, USA, 4Department of Pathology, Hospital of St Raphael, New Haven, CT, USA, 5Department of Pediatrics, Louisiana State University Health Sci...
OBJECTIVE Epithelioid angiomyolipomas (AML) of the kidney are malignant tumors with aggressive clinical behavior. METHODS The Authors report on some cases epithelioid AM recently diagnosed at their Institute to highlight the spectrum of clinical presentations. RESULTS In all cases, renal lesions observed at computed tomography were suspicious for renal cell carcinoma (RCC). Histologically, ...
Genetic studies have shown that the tuberous sclerosis complex (TSC) 1-TSC2-mammalian target of Rapamycin (mTOR) and the Hippo-Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often involved in tumorigenesis. The crosstalk between these signal transduction pathways in coordinating environmental cues, such as nutritional status and mechanical constraints, is...
Epithelioid angiomyolipoma (EAML) of the kidney is an uncommon neoplasm with malignant potential. It can occur sporadically or be associated tuberous sclerosis. EAML a monotypic variant (AML), which classified as perivascular epithelioid cell tumor. Due to its nature and paucity fat components, unlike classic AML, has abundant adipose tissue characteristic features on CT scans, it difficult dis...
Perivascular epithelial cell tumors (PEComas), firstly described by Bonetti in 1992, are a family of mesenchymal tumor composed of perivascular epithelioid cells having epithelioid or spindle morphology and exhibiting melanocytic and myogenic immunoreactivities. We herein described a 61-year-old woman who presented with epigastric pain. Preoperative imaging studies showed that 7-cm-sized mass w...
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