Behçet’s ‎disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...

brucellosis is an infectious disease with high incidence in iran. neurobrucellosis is a focal complication of brucellosis affecting both central and peripheral nervous system presenting with a varieties of signs and symptoms. the most reported manifestations are meningitis and meningoencephalitis. in this report, we will describe a case of a young woman affected by neurobrucellosis presenting w...

Diseases of the ear often cause signs of neurologic dysfunction because of damage of peripheral nervous system structures associated with the middle and inner ear. Vestibular dysfunction, facial paralysis, Horner's syndrome, and hearing deficits are the most common neurologic deficits that accompany middle and inner ear disease. Differentiating these signs from disease of the central nervous sy...

multiple  sclerosis  (ms) is  an  autoimmune  multifactorial  degenerative  disease  with detrimental affliction on central nervous system. mhc class i chain- related genea,b(mica and micb) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation. the purpose of this study was to evaluate the mica and micb mrna expression in multiple sclerosis patie...

primary sjorgen syndrome is one of the commonest autoimmune diseases with characteristic of involvement of lachrymal and salivary glands, but other organ involvements as peripheral and central nervous system are also possible. the reported case is a 23 year old lady presented with progressive sensory ataxia and weakness of four limbs, bilateral sensory hearing loss and cognitive impairment with...

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function the peripheral central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, high-affinity receptor for involved physiological pathological aspects via affecting viability, function, neurogenesis, cognitiv...

Alterations of autophagy have been linked to several peripheral nervous system diseases, such as amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease. Modulation of autophagy by metabolic or pharmacological interventions has been increasingly recognized as a strategy to fight many of these disorders. Cellular processes that are aberrant in case of impaired autophagy and that might lead...

Correspondence to: Professor R Hughes, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; richard. [email protected] EPIDEMIOLOGY Peripheral nerve diseases are surprisingly common. Population-based studies indicate a prevalence of symmetrical polyneuropathy of about 2.4%, more in the elderly. Carpal tunnel synd...