THE development of ultrafine surgical sutures with low tissue reactivity, more efficient optical equipment, and specialized microsurgical instrumentation has produced important advances in morphologic and functional recovery of peripheral nerves. Studies have shown that appropriate axonal apposition, minimal manipulation, and sustentation of nervous tissue can contribute to nerve regeneration. ...

vidence for a role of the immune system in neuropathy and neuropathic pain is increasing.1 It is now estimated that half of all clinical cases of neuropathic pain are associated with infection or inflammation of peripheral nerves rather than with nerve trauma.2 Animal models have now been developed to explore the nociceptive impact of immune activation in and around nerve trunks, dorsal root ga...

Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that in vivo visualises random translational movement of water molecules. DTI has inherent difficulties with low signal-to-noise ratio, sensitivity to patient motion, field inhomogeneities and fast T2 relaxation. It has been used in the central nervous system, although it has not been assessed in the peripheral nervous sys...

Nerves and blood vessels are branched structures, but whether their branching patterns are established independently or coordinately is not clear. Here we show that arteries, but not veins, are specifically aligned with peripheral nerves in embryonic mouse limb skin. Mutations that eliminate peripheral sensory nerves or Schwann cells prevent proper arteriogenesis, while those that disorganize t...

The fate of patients with leukemia has greatly improved in the past decades. Survival has been increased and the once stereotypic pattern of Cerebrospinal fluid (CSF) infiltration and diffuse infiltration of nerves and muscles has entirely changed. Peripheral nervous structures as cranial nerves, nerve roots, plexus and peripheral nerves can be affected in different types of leukemia, by differ...

Studies of peripheral nerves in two different lines of hypomyelinating transgenic mice support the hypothesis that myelinating Schwann cells exert a significant influence on key biological properties of axons. The mice contain transgenes combining the peripheral myelin protein zero gene (P0) promoter and either the diphtheria toxin A chain gene product or the SV40 (simian virus 40) large T anti...

The peripheral nerves consist of sensory nerves that transmit somatic and visceral afferent information to the brain via the spinal cord and motor nerves that convey efferent outputs of the brain to effector organs such as skeletal muscles and glands. The nerve conduction velocities (NCV) of mammalian peripheral nerves range from 10 m/s to 150 m/s, depending on the type of information being tra...

The frequency of peripheral nerve involvement in sarcoidosis is uncertain. To determine how often peripheral nerves are affected in the absence of symptoms, electromyography was performed on 29 sarcoid patients and 29 age-matched controls. Nineteen sarcoid patients, compared to two controls, had abnormally low sensory amplitudes in one or more nerves, and the mean sensory amplitudes for median,...

Background/introduction MR-guided HIFU is an effective treatment for metastatic bone pain through periosteal nerve ablation,[1] and is being investigated for treating back pain through facet joint denervation.[2] For peripheral neuropathy, ultrasound-guided HIFU has been investigated preclinically as a means of achieving either an irreversible conduction block to treat severe spasticity [3], or...