Aim: To elucidate the outcome for very low birth weight infants delivered after preterm premature rupture of membranes (PPROM) managed conservatively, and to determine the prognostic value of perinatal factors for long-term outcome. Methods: Perinatal data were collected from medical records for singleton live-birth infants delivered between 1991 and 2008 after conservatively managed PPROM. Cas...

OBJECTIVE To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome. METHODS A total of 184 PT and 32 full-term infants underwent magnetic resonance imaging at term equivalent age with manual segmentation of the hippocampi on coronal slices. Perinatal data were coll...

BACKGROUND AND PURPOSE The objective was to investigate the role of infant and maternal thrombophilia in a cohort of mothers and infants presenting with perinatal arterial ischemic stroke. METHODS Forty-seven infants with clinically and radiologically confirmed perinatal arterial ischemic stroke underwent thrombophilia workup: factor V Leiden (FVL), PII20210A mutation, Methylene-tetrahydrofol...

Hypoxia-ischemia constitutes a risk in infants by altering cerebral blood flow regulatory mechanisms and causing loss of cerebral vascular auto-regulation. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation leading to cell death and tissue damage. These dramatic phenomena represent a common repertoire in infants complicated by perinatal acut...

OBJECTIVES To predict neonatal mortality and length of stay (LOS) from readily available perinatal data for neonatal intensive care unit (NICU) admissions in Southern African private hospitals. METHODS Retrospective observational study using perinatal data from a large multicentre sample. Fifteen participating NICU centres in the Medi-Clinic private hospital group in Southern Africa. We used ...

This study determines the perinatal mortality rate (PMR) among births recorded at the Women's Patna Medical College Hospital (PMCH) in India, and from other centers in the Patna district community, where the ICDS program was not implemented. Births include all infants over 28 weeks of gestational development and who weighed over 1000 g at birth. Infants were grouped by birth weights as follow...

PURPOSE To establish a normative range of intraocular pressure (IOP) in preterm infants and to identify important perinatal factors that could affect the IOP during the early weeks of neonatal life. METHODS The IOP of 104 preterm infants, with a median (interquartile range) gestational age of 29.8 (28.7-30.9) weeks and birth weight of 1208 (1049-1370) g, were assessed in a university-affiliat...

BACKGROUND Recent advances in perinatal technology have dramatically increased the survival of very low birth weight (VLBW) infants (<1500 g). The possibility that these advances may also prolong the time to death and increase pain and suffering has been of concern, but there have been no population-based evaluations of this issue. METHODS Infant, neonatal, and postneonatal mortality rates an...

Perinatal hypoxia results in neuronal and endothelial cell damage. The main purpose of this study was to investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) expression and peripheral blood changes in perinatal asphyxia with neuronal injury markers in low birth weight (LBW) neonates. We compared the concentrations of serum sICAM-1, neuron-specific enolase (NSE) and...