Background: Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the spinal cord of rats. We assessed the expression of c-Fos in response to intraplantar formalin in the lumbar regions of the spinal cord in consciou...

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...

background: xanthomonas citri subsp. citri (xcc), the causative agent of bacterial citrus canker, has affected citriculture worldwide. varieties of means have been used to minimize its devastating effects, but no attention has been given to bacteriocins.objectives: here and for the first time, we report the isolation and characterization of two novel bacteriocins.materials and methods: secretom...

the proline-rich β-casein was digested in vitro with trypsin, and the oligopeptides producedwere then isolated by rp-hplc and subsequently identified by amino acid analysis and ion massspectrometry. the peptide fractions from the complete digestion were then treated with purified x-prolyldipeptidyl peptidase (x-pdp) extracted from lactobacillus casei ssp. casei llg. two bitter peptides (f53-97a...

In this work, peptides were extracted from Silver carp (SC) scales via protease hydrolysis and separated using two membranes (M1 M2). The results revealed that the water: SC scale ratios of 50.6 mL/g, alkaline 1 (AP1) dose 2313.6 U/mL, pH 8.14 optimal conditions, peptide yield reached 88.77 ± 0.32%. conditions separation clarified: operating pressure M1 (M2) was 0.25 (0.4) MPa, liquid temperatu...

Oral administration of food protein hydrolysate and naturally occurring peptides exert beneficial effects beyond conventional nutritional functions by supplying amino acids for synthesis. These are referred to as food-derived bioactive peptides. The coronavirus disease 2019 (COVID-19) is caused sever acute respiratory syndrome 2 (SARS-CoV-2) infection. Some host viral proteins involved in the e...

We report coupled cluster, MP2 and DFT data on the relative energy geometry of α-sheet β-strand conformations model peptides. show that ionic effects have a strong effect balance through formation multiple cation-oxygen contacts in form. Such are markedly dependent both sequence ion: two peptides considered favour presence cations, whereas third, non-polar one favours same conditions.

The preface of this multi-authored book states that it wishes to acquaint the neophyte with the current information in the field of arteriosclerosis, as well as help the experienced worker correlate his research findings with those from other disciplines. For some it will be a valuable book. However, from the point of view of the experienced worker it lacks depth; for the neophyte it may be sli...

epidermal growth factor (egf) is a polypeptide molecule, with important functions in epithelial growth and wound repair. it exerts its effects on cells by binding to receptors on the cell surface. the aim of this study was to evaluate and compare salivary egf levels in patients with gingivitis and advanced periodontitis as well as in healthy controls.unstimulated salivary samples were collected...

background: cystatin c (cys c) has been implicated as a prognostic marker in cardiovascular disease. the aim of this study was to evaluate the value of cys c as a marker of acute kidney injury (aki) in acute heart failure (ahf), the impact of cys c and n-terminal probrain natriuretic peptides (nt-probnp) on in-hospital and 12 months mortality were also investigated. materials and methods: a tot...