OBJECTIVES To evaluate antibiotic consumption in the pediatric wards of Emilia-Romagna Region, from 2004 to 2011, with a focus on the antibiotics reserved to the most serious infections, and to analyse the ADRs reported for antibiotics by the pediatric wards of Emilia-Romagna hospitals. METHODS Reference population was represented by all the patients (0-14 years old) admitted to the pediatric...

PURPOSE Adverse drug reactions (ADRs) including medication allergies are not well-described among large national cohorts. This study described the most common documented medication allergies and their reactions among a national cohort of Veterans Affairs (VA) inpatients. METHODS We evaluated inpatient admissions in any VA Medical Center from 1 January 2000 to 31 December 2014. Each admission ...

OBJECTIVE To describe the frequency and characteristics of antibiotic prescribing for different types of contacts with the Danish out-of-hours (OOH) primary care service. DESIGN Population-based observational registry study using routine registry data from the OOH registration system on patient contacts and ATC-coded prescriptions. SETTING The OOH primary care service in the Central Denmark...

The clinical Klebsiella pneumoniae INSRA6884 strain exhibited nonsusceptibility to all penicillins tested (MICs of 64 to >2,048 μg/ml). The MICs of penicillins were weakly reduced by clavulanate (from 2,048 to 512 μg/ml), and tazobactam restored piperacillin susceptibility. Molecular characterization identified the genes bla(GES-7) and a new β-lactamase gene, bla(SHV-107), which encoded an enzy...

Penicillins are used universally in both human and veterinary medicine. The European Union (EU) has established maximum residue levels (MRLs) for most ss-lactam antibiotics in milk and animal tissues and included them in the National Residue Monitoring Programs. In this study, a novel method is described for the determination and confirmation of eight penicillins in porcine tissues, milk and an...

Lee, H. J . , P . D. Ryu, H. Lee, M. H. Cho, M. H. Lee:Screening for Penicillin Plasma Residues in Cattle by Enzyme-Linked Immunosorbent Assay. Acta Vet. Brno 2001, 70: 353–358. In this study, we established a rapid prediction test for the detection of the cattle with violative tissue residues of penicillins. The recommended therapeutic doses of two penicillins, ampicillin (withdrawal time, 6 d...