conclusions: prevalence of hsv1/2 in mucocutaneous biopsies from pemphigus patients is 2.5% and possibly hsv1/2 has no role in the pathogenesis of pemphigus lesions. but resistant cases to treatment might be suspected to hsv. results: ten patients (25%) had a history of orolabial herpes infection. the results of all samples were negative for hsv1 except one sample which showed the positive resu...

Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may play a significant role in autoimmune diseases such as pemphigus vulgaris. Only a few studies h...

Pemphigus vulgaris is a serious chronic mucocutaneous ailment. In recent decades advances in diagnostic and therapeutic measures have led to a significant decline in morbidity and mortality. However, with the advent of active and prolonged immunotherapy involving corticosteroids, there has been a rise in steroid-associated complications. This has led to significant concern globally over the sen...

We describe a 39-year-old woman with an apparent captopril-induced, contact mucosal-dominant pemphigus vulgaris and angioedema, who took captopril during a bout of arterial hypertension. This exposure suggests that captopril and pathophysiology of angioedema stimulated the development of pemphigus vulgaris, which was diagnosed using the novel, indirect immunofluorescence BIOCHIP mosaic, with th...

In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesion...

d-penicillamine is one of the disease-modifying anti-rheumatic drugs (dmards). drug-induced pemphigus is not frequently associated with d-penicillamine, and to date, the number of reported cases is about a hundred. most reports of d-penicillamine-induced pemphigus vulgaris are in patients with rheumatoid arthritis. it has rarely been reported in patients not taking d-penicillamine. we report a ...

The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-alpha promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-alpha gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphig...

BACKGROUND Measuring the quality of life (QOL) is important in the evaluation of nonclinical aspects of diseases, for the discovery of functional and psychological limitations, and in choosing treatment in the initial phase of the disease. Pemphigus is a potentially fatal autoimmune bullous disease caused by autoantibodies against desmogleins (cadherin family proteins in desmosomes). Thus far, ...

After so many years of learning about the epidemiology, nature, diagnosis and management of the pemphigus group and other bullous dermatoses at University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, it was wonderful to discover – from the oral presentation entitled “Bullöse Dermatosen 2007” held by Prof. Michael Hertl in Graz (Austria) at...

Although psoriasis and bullous diseases are considered to be completely different disease entities, the literature has reported a few cases of psoriasis associated with bullous diseases, most of which are bullous pemphigoid. In limited cases, pemphigus foliaceus has also been reported in association with psoriasis. In most of them, pemphigus lesions usually developed on an untreated patient wit...