نتایج جستجو برای: pegylated dendrimers

تعداد نتایج: 9179  

B. Klajnert C. Demetzos D. Wróbel J. P. Majoral K. Gardikis M. Bryszewska M. Ionov, S. Hatziantoniou

Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids tha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Jean M J Fréchet

S ince their introduction in 1985 by Tomalia et al. (1) and Newkome et al. (2), dendrimers have attracted much attention because of their fascinating structure and unique properties (3, 4). Dendrimers are globular, size monodisperse macromolecules in which all bonds emerge radially from a central focal point or core with a regular branching pattern and with repeat units that each contribute a b...

Journal: :Organics 2022

Dendrimers are highly branched macromolecules possessing, in most cases, identical terminal functions. However, it is sometimes desirable to have two types of surface functions order fulfil specific properties. The stochastic functionalization frequently used for such purposes, but the presence an uncontrolled number each type function, albeit acceptable research has no practical use. Thus, fin...

Journal: :Molecules 2012
Katarzyna Winnicka Magdalena Wroblewska Piotr Wieczorek Pawel Tomasz Sacha Elzbieta Tryniszewska

Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH(2) and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evalu...

Journal: :Environmental science & technology 2008
Mamadou S Diallo Wondwossen Arasho James H Johnson William A Goddard

Chelating agents are widely employed in many separation processes used to recover uranyl [U(VI)] from contaminated aqueous solutions. This article describes an experimental investigation of the binding of U(VI) to poly(amidoamine) [PAMAM] and poly(propyleneimine) [PPI] dendrimers in aqueous solutions. We combine fluorescence spectroscopy with bench scale ultrafiltration experiments to measure t...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2014
Hiroki Sakae Hirohisa Nagatani Kotaro Morita Hisanori Imura

Molecular encapsulation of anionic porphyrins in NH2-terminated polyamidoamine (PAMAM) dendrimers and the interfacial behavior of the dendrimer-porphyrin associates were studied at the polarized water|1,2-dichloroethane (DCE) interface. Formation of the ion associates was significantly dependent on the pH condition and on generation of dendrimers. 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
I Posadas L Romero-Castillo N El Brahmi D Manzanares S Mignani J-P Majoral V Ceña

Inflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites. Innate immunity, mediated by mononuclear phagocytes, including monocytes and macrophages, is a first line of defense against infectious diseases and plays a key role triggering the delayed adaptive response that ensures an efficient defens...

Journal: :New journal of chemistry = Nouveau journal de chimie 2009
Meredith A Mintzer Olivia M Merkel Thomas Kissel Eric E Simanek

A panel of eight, second generation triazine dendrimers differing in the number of amines, guanidines, hydroxyls and aliphatic groups on the periphery was synthesized and assayed for gene transfer in an attempt to correlate the effects of surface functionality on transfection efficiency. The physicochemical and biological properties of the dendrimers and dendriplexes, such as condensation of DN...

Journal: :Langmuir : the ACS journal of surfaces and colloids 2004
M Francesca Ottaviani Steffen Jockusch Nicholas J Turro Donald A Tomalia Antonio Barbon

Interactions of polyamidoamine dendrimers, termed Gn, where n indicates the generation (=number of amidoamine layers), at different protonation levels with selected amino acids and proteins have been investigated by means of continuous wave electron paramagnetic resonance (cw-EPR) and pulsed-EPR (electron spin-echo = ESE) analyses. A low-generation dendrimer (G2) and a high-generation one (G6) ...

Journal: :Journal of the Japan Society of Colour Material 2002

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