The human population is widely exposed to polyethylene glycol (PEG) and its chemical derivatives, which are widely used as vehicles or co-solvents in many pharmaceutical and cosmetic preparations. However, PEG polymers of low molecular weight differ significantly from polymers of higher molecular weight in their physico-chemical properties, biological effects on cell permeability and their abso...

In the preformulation study physical compatibility of the drug-excipient was screened and compatibility was observed between Zaltoprofen and selected solubilizers. In the drug solubilizers interference study no interference was observed in UV spectrophometric analysis of Zaltoprofen in presence of employed solubilizers. Aqueous solubility of Zaltoprofen was found 0.028 mg/ml. The solubilizers s...

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.

A simple and convenient route is described for the synthesis of novel hetero 1,3-diaryl-2-propen-1-ones (chalcones) by using recyclable PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). All the synthesized compounds were evaluated for their antimicrobial activities against sever...

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

A novel method for the synthesis of 2,6-dihydroxy substituted chalcones via Claisen-Schmidt is introduced using recyclable PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). The structures of the synthesized compounds were confirmed by IR, mass spectroscopy and elemental analysis.

In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1Himidazol-5-yl)methylene)benzofuran-3(2H)-ones. Newly synthesized compounds were tested for their in vitro antimicrobial activity.

The apparent solubilities of various proteins (14,000 to 670,000 daltons) were measured in the presence of polyethylene glycols (PEGs) of different sizes. All of the solubility curves, determined by measuring the protein concentration in the supernate of centrifuged mixtures, exhibited the characteristic linear dependence of log S (g/liter) on PEG concentration (%, w/v). For human albumin in PE...