a. We recommend that unenhanced computed tomography is the preferred imaging modality for the diagnosis of suspected nephrolithiasis in autosomal dominant polycystic kidney disease (1B). b. We recommend that patients with autosomaldominant polycystic kidney disease complicated by nephrolithiasis should be investigated for predisposing urinary metabolic abnormalities (1C) and we suggest receive ...

PURPOSE To study whether -160 C > A (rs16260) and -347 G > GA (rs5030625) single nucleotide polymorphisms of the regulatory region (rSNPs) of CDH1 gene modulate the risk of nephrolithiasis. METHODS Genomic DNA of 101 patients with calcium oxalate nephrolithiasis and 114 healthy controls were screened for both polymorphisms, using polymerase chain reaction-restriction fragments length polymorp...

The association between nephrolithiasis and acromegaly has been previously described. Although the mechanism has been established, the urological literature sparsely discusses clinically suspecting that patients with recurrent nephrolithiasis could have acromegaly and subsequently referring them for accurate diagnosis and treatment. We present a case of occult acromegaly secondary to a pituitar...

Introduction: Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract. Biologic drugs target specific molecules in body’s immune system to control inflammation. Recent studies have suggested potential link between their use and an increased risk nephrolithiasis. We conducted study further investigate this association. Methods: The used multiple logistic regre...

background nephrolithiasis is a widespread multifactorial disorder. constitutional, environmental and genetic factors play a role in stone formation. although important advances have been made in understanding the pathophysiology of stone formation, none of the many theories have given a satisfactory explanation of this process. objectives the objective of study was to evaluate the probable rel...

Aim: Urinary reflux is a probable reason of nephrolithiasis among children. This study aimed to assess the relationship between urinary reflux and other reason of stone formation in children.Methods: This cross-sectional study was carried out with 199 children diagnosed with nephrolithiasis using ultrasonography. They were hospitalized in a referral children hospital in an urban area of in Iran...

Our understanding of the molecular basis of cystinuria has deepened as the result of the causative genes, SLC3A1 and SLC7A9, being identified. The proteins coded for by these genes form a heterodimer responsible for reabsorption of filtered cystine in the proximal tubule. Failure of this transport system to be targeted to the apical membrane, as in the case of SLC3A1 mutations, or failure of th...