OBJECTIVE To construct an updated comorbidity index (Patient Register Index [PRI]) using national data collections from Norway and compare its predictive ability of 1-year mortality with the Charlson Comorbidity Index (CCI). MATERIALS AND METHODS Data regarding over 1.11 million patients registered in the Norwegian Patient Register in 2010 and 2011 were used to construct the PRI. The PRI was ...

Human placental ribonuclease inhibitor (PRI) abolishes both the ribonucleolytic activity of angiogenin toward 28S and 18S rRNA and its angiogenic activity on the chicken embryo chorioallantoic membrane. Treatment of the angiogenin-PRI complex with p-hydroxymercuribenzoate releases enzymatically active angiogenin. Assays measuring competition between angiogenin and bovine pancreatic ribonuclease...

We have previously reported that the RNA-binding protein Dull slicer 16 (DUS16) plays a key role in the processing of primary miRNAs (pri-miRNAs) in the unicellular green alga Chlamydomonas reinhardtii. In the present report, we elaborate on the interaction of DUS16 with Dicer-like 3 (DCL3) during pri-miRNA processing. Comprehensive analyses of small RNA libraries derived from mutant and wild-t...

Light use efficiency (LUE) models are widely used to estimate gross primary productivity (GPP), a dominant component of the terrestrial carbon cycle. Their outputs are very sensitive to LUE. Proper determination of this parameter is a prerequisite for LUE models to simulate GPP at regional and global scales. This study was devoted to investigating the ability of the photochemical reflectance in...

Several studies have confirmed the crucial roles of microRNAs (miRNAs) in cancer occurrence. In addition, single nucleotide polymorphisms (SNPs) in miRNA genes have been associated with various cancers. The aim of the present study was to investigate the association of SNPs in miRNA genes with cervical intraepithelial neoplasia (CIN) and cervical cancer in a Chinese Han population. We searched ...

In the present study, we evaluated the antitumor effect of two synthetic analogs of vitamin D, namely PRI-2191 [(24R)-1,24-dihydroxyvitamin D3] and PRI-2205 (5,6-trans calcipotriol), in combined human colon HT-29 cancer treatment with 5-fluorouracil (5-FU). Mice bearing HT-29 tumors transplanted subcutaneously or orthotopically were injected with vitamin D analogs and 5-FU in various schedules....

The active form of 1,25-dihydroxyvitamin D(3) prevents neuronal damage in vitro and in vivo , however, it induces also hypercalcemia and hyperphosphatemia. Side-chain-modified analogues of 1,25-dihydroxyvitamin D(3), which show low calcemic activity, may be potentially useful in the treatment of some neurodegenerative diseases. Previously, we have found that PRI-2191 more potently than 1,25-dih...

supreme jurists have focused on sixth verse of sura tobeh to legitimize refuge in islam and assigned it to unbelievers. however, deliberating on other verses of holy quran, traditions and juristically regulations we can justify new issues which haven’t mentioned by supreme jurists. referring to the juridical books and various interpretations of holy quran to develop the concept of refuge this e...

The global marine environment has been impacted significantly by climate change. Ocean temperatures are rising, and the frequency, duration intensity of heatwaves increasing, particularly affecting coral reefs. Coral bleaching events becoming more common, with less recovery time between events. Anomalous at start 2020 caused widespread across Great Barrier Reef (GBR), extending to southern, pre...

The photochemical reflectance index (PRI) is a proxy for light use efficiency (LUE), and is used in remote sensing to measure plant stress and photosynthetic downregulation in plant canopies. It is known to depend on local light conditions within a canopy indicating non-photosynthetic quenching of incident radiation. Additionally, when measured from a distance, canopy PRI depends on shadow frac...