For patients with locally unresectable recurrent nasopharyngeal carcinoma who relapsed after 2 years of radiotherapy, re-radiotherapy is also the preferred treatment. However, for within years, use would be greatly limited by its adverse effects. Consequently, finding a new strategy to prolong time very necessary reduce related side effects and improve curative effect. Anlotinib an orally avail...

Brain arteriovenous malformation (bAVM) is the most common cause of intracranial hemorrhage (ICH), particularly in young patients. However, exact bAVM bleeding and rupture not yet fully understood. In bAVMs, blood bypasses entire capillary bed directly flows from arteries to veins. The vessel walls bAVMs have structural defects, which impair vascular integrity. Mural cells are essential functio...

OBJECTIVES This study sought to examine the role of platelet-derived growth factor (PDGF) signaling in healing myocardial infarcts. BACKGROUND Platelet-derived growth factor isoforms exert potent fibrogenic effects through interactions with PDGF receptor (PDGFR)-alpha and PDGFR-beta. In addition, PDGFR-beta signaling mediates coating of developing vessels with mural cells, leading to the form...

The growth of neointima and neointimal smooth muscle cells in baboon polytetrafluoroethylene grafts is regulated by blood flow. Because neointimal smooth muscle cells express both platelet-derived growth factor receptor-alpha and -beta (PDGFR-alpha and -beta), we designed this study to test the hypothesis that inhibiting either PDGFR-alpha or PDGFR-beta with a specific mouse/human chimeric anti...

Abstract This phase Ib study enumerated whole blood circulating tumor cells (CTC) and evaluated biomarkers in patients with potentially resectable soft-tissue sarcoma (STS) treated olaratumab monotherapy (20 mg/kg) for one cycle followed by up to six cycles of mg/kg, 1–2; 15 3–7) plus doxorubicin (75 mg/m2 on day 1). CTCs, platelet-derived growth factor receptors (PDGFR), PDGF ligand expression...