نتایج جستجو برای: pde inhibitor

تعداد نتایج: 218917  

Journal: :European journal of pharmacology 2008
António José Santos-Silva Elisa Cairrão Manuel Morgado Ezequiel Alvarez Ignacio Verde

Cyclic nucleotides (cAMP and cGMP) are the main second messengers linked to vasodilatation. They are synthesized by cyclases and degraded by different types of phosphodiesterases (PDE). The effect of PDE inhibition and cyclases stimulation on 5-hydroxytryptamine (5-HT; 1 microM) and histamine (10 microM) contracted arteries was analysed. Stimulation of guanylate cyclase or adenylate cyclase rel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Michael-Claude G Beltejar Ho-Tak Lau Martin G Golkowski Shao-En Ong Joseph A Beavo

Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet been identified in most cell types. Conventional approaches to study PDE function typically rely on measurements of global cAMP, general increases in cAMP-dependent protein kinase (PKA), or the activity of exchange protein activated by cAMP (EPAC). Although newer approaches using subcellularly targeted FRE...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008
Bernd Hohenstein Christoph Daniel Sandra Wittmann Christian Hugo

BACKGROUND Matrix expansion and mesangial proliferation are hallmarks of mesangial proliferative glomerulonephritis. Specific inhibition of PDE-5, an enzyme catalyzing the intracellular degradation of cyclic GMP, can be achieved by the inhibitor vardenafil. In this study, we investigated the effects of PDE-5 inhibition in the anti-Thy1 model in the rat in vivo. METHODS After disease induction...

Journal: :Journal of oral science 2009
Keitaro Satoh Ming-Yu Guo Nakayasu Sairenji

beta-Adrenoceptor activation increases intracellular cAMP levels and consequently induces exocytotic amylase release in parotid acinar cells. Phosphodiesterase (PDE) catalyses the hydrolysis of cAMP, which terminates the downstream signaling of this second messenger. We investigated the involvement of PDE4, a cAMP-PDE, in beta-adrenoceptor agonist-induced amylase release in mouse, rat and rabbi...

Journal: :iranian journal of radiation research 0
g. sharma neurobiology lab, department of zoology, university of rajasthan, jaipur, india r. sisodia neurobiology lab, department of zoology, university of rajasthan, jaipur, india e. meghnani mahatma gandhi institute of applied sciences, jaipur, india

background: the increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel’s charged with the responsibility of working or testing with radiations in laboratories, but also for general public. with this view the present study has been undertaken to determine the deleterious effects of sub lethal gamma r...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Lucia De Franceschi Orah S Platt Giorgio Malpeli Anne Janin Aldo Scarpa Christophe Leboeuf Yves Beuzard Emmanuel Payen Carlo Brugnara

Pulmonary arterial hypertension (PAH) is one of the leading causes of morbidity and mortality in adult patients with sickle cell disease (SCD). Here, we developed a model to study the early stage of PAH in SCD. We exposed wild-type and transgenic sickle cell SAD (Hbb(s)/Hbb(s)) mice to hypoxia (8% O(2)) for 7 days. Prolonged hypoxia in SAD mice only induced 1) increased neutrophil count in both...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2013
Elizabeth A Townsend Charles W Emala

Asthma is a disease of the airways with symptoms including exaggerated airway narrowing and airway inflammation. Early asthma therapies used methylxanthines to relieve symptoms, in part, by inhibiting cyclic nucleotide phosphodiesterases (PDEs), the enzyme responsible for degrading cAMP. The classification of tissue-specific PDE subtypes and the clinical introduction of PDE-selective inhibitors...

Journal: :European journal of endocrinology 2000
M O Velardez A De Laurentiis M del Carmen Díaz M Lasaga D Pisera A Seilicovich B H Duvilanski

OBJECTIVE In order to determine the mechanism by which nitric oxide (NO) inhibits prolactin release, we investigated the participation of cGMP-dependent cAMP-phosphodiesterases (PDEs) and protein kinase G (PKG) in this effect of NO. METHODS Anterior pituitary glands of male rats were incubated with inhibitors of PDE and PKG with or without sodium nitroprusside (NP). Prolactin release, and cAM...

Journal: :Pharmacological reviews 2006
Andrew T Bender Joseph A Beavo

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation, ...

2017
Shipeng Gong Yongning Chen Fanliang Meng Yadi Zhang Huan Wu Fei Wu

The abrogation of cAMP generation by overexpression of PDE isoforms promotes the inflammatory pathology, and the PDE inhibitors have showed the potential anti-inflammation effects in clinical. However, the function of PDE inhibitors in cancer treatment remains unclear. We here investigated the role of PDE4 inhibitor Roflumilast in the treatment of ovarian cancer. We found that Roflumilast could...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید