Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years. Development of chemical inhibitors for this pathway lags the antibody development because of insufficient structural information. The first nonpeptidic chemical inhibitors that target the PD-1/PD-L1 interaction have only been recently disclosed b...

Reactivity studies of a Pd(II)-verdazyl complex reveal novel ligand-centred reduction processes which trigger pseudo-reductive elimination at Pd. Reaction of the complex with water induces a ligand-centred redox disproportionation. The reduced verdazyl ligands can also be reversibly protonated.

Parkinson's disease (PD) is a common neurodegenerative disease. However, therapeutic methods of PD are still limited due to complex pathophysiology in PD. Here, optical measurements of individual neurons from in vitro PD model using optical diffraction tomography (ODT) are presented. By measuring 3D refractive index distribution of neurons, morphological and biophysical alterations in in-vitro ...

In the title complex, [PdBr(C(4)H(3)N(2))(C(18)H(15)P)(2)], the geometry around the Pd atom is distorted square-planar with the Pd atom displaced by 0.0334 (14) Å from the BrP(2)C plane. The two Ph(3)P ligands are in trans positions, defining a P-Pd-P angle of 171.78 (5)°, while the pyrimidinyl and bromide ligands are trans to each other [C-Pd-Br = 174.63 (14)°].

Dysfunction of mitochondrial complex I is associated with a wide spectrum of neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of complex I leads to degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNpc), as seen in PD, through activation of mitochondria-dependent apoptotic molecular pathways. In this scenario, complex I blockade ...

In the title complex, [Pd(2)(C(11)H(8)N)(2)(C(2)H(3)O(2))(2)], each Pd(II) ion has a distorted square-planar environment, being surrounded by one C, one N and two O atoms. The Pd⋯Pd distance is 2.8721 (3) Å. In the crystal structure, the mol-ecules are linked by inter-molecular C-H⋯O inter-actions.

Parkinson's disease (PD), the second most frequent neurodegenerative disease, fits within the wide range of complex polygenic disorders influenced by both genetic and environmental factors. In fact, just around 10% of PD cases are familial, caused by monogenic forms which sometimes exhibit incomplete penetrance. The vast majority of PD cases are sporadic and often present with varied clinical p...

In the title complex, cis-[PdI(2)(C(6)H(16)N(2))], the Pd(II) atom lies on a crystallographic twofold rotation axis and is four-coordinated by the two N atoms of a chelating N,N,N',N'-tetra-methyl-ethylenediamine ligand [Pd-N = 2.125 (3) Å] and two I atoms [Pd-I = 2.5833 (4) Å], displaying a distorted square-planar geometry (r.m.s. deviation = 0.005 Å), imposed by the small bite of the chelatin...

Substitution reactions of the complexes [Pd(bpma)(H2O)]2+ and [Pt(bpma)(H2O)]2+, where bpma = bis(2-pyridylmethyl)amine, with TU, DMTU and TMTU for both complexes and Cl-, Br-, I- and SCN- for the platinum complex, were studied in aqueous 0.10 M NaClO4 at pH 2.5 using a variable-temperature stopped-flow spectrophotometer. The pKa value for the coordinated water molecule in [Pd(bpma)(H2O)]2+ (6....