Amyotrophic lateral sclerosis 8 (ALS8) is a rare progressive neurodegenerative disease resulting from mutation in the gene for vesicle-associated membrane protein-associated protein B. We evaluated a North American patient using exome sequencing, and identified a P56S mutation. The disease protein had similar subcellular localization and expression levels in the patient and control fibroblasts....

Extracorporeal membrane oxygenation (ECMO) may be a life-saving procedure for patients with severe reversible pulmonary or cardiac failure or for patients in need for a bridge to transplantation. ECMO is provided by specialized centers, but patients in need of ECMO are frequently taken care of at other centers. Conventional transports to an ECMO center can be hazardous and deaths have been desc...

OBJECTIVE To determine what complications children have during interhospital transfer for intensive care, and how often these complications occur. DESIGN Observational study of all children transferred over a six month period, including interviews with patient escort, patient review, and severity of illness scoring. MAIN OUTCOME MEASURES Timing and method of transport; complications occurri...

[1-3]. Barratt and colleagues studied patients transferred for nonclinical reasons to evaluate the consequences of transportation [4]. Th ere was no diff erence in mortality but the ICU length of stay (LOS) increased by 3 days, which was explained as a negative impact of the transport on patient physiology. We disagree with this conclusion. First, by including only transports to level 3 ICUs th...

Background Transporting critically ill patients between hospitals may be hazardous. Treatment of medical emergencies is paramount, and delivery of drugs during a medical emergency on patient transport may be lifesaving. Currently, there is no standardized crash cart and no guidelines on which drugs physicians should bring when escorting patients. There is increasing evidence that system differe...

PURPOSE Recovery and discharge following ambulatory surgery are important components of the ambulatory surgery experience. This review provides contemporary perspectives on the issues of discharge criteria, fast-tracking, patient escort requirements, and driving after ambulatory anesthesia. SOURCE A search was performed in the Cochrane Central Register for Controlled Trials, MEDLINE(R), EMBAS...

Sediment transport under unsteady flow condition is studied experimentally. In the first step, sediment transport under different steady flow conditions was measured and an empirical equation was derived for its calculation. In the next step, two continuous and three stepwise hydrographs were generated in the flume, and their sediment transport rate was measured. The continuous hydrographs were...

BACKGROUND This review on the current literature of the intrahospital transport of critically ill patients addresses type and incidence of adverse effects, risk factors and risk assessment, and the available information on efficiency and cost-effectiveness of transferring such patients for diagnostic or therapeutic interventions within hospital. Methods and guidelines to prevent or reduce poten...

BACKGROUND There are three different types of ambulance systems, all of which can manage the same secondary intensive care patient transport mission: road ambulance, rotor-wing ambulance, and fixed-wing ambulance. We hypothesized that costs for specific transport distances would differ between systems. We aimed to analyze distances and observed times for ambulance intensive care secondary trans...