AIMS AND BACKGROUND The pretreatment serum carcinoembryonic antigen (CEA) level is an independent prognostic factor in colorectal cancer. We aimed to investigate the significance of CEA as a prognostic or predictive factor in rectal cancer patients receiving preoperative chemoradiotherapy (CRT). METHODS AND STUDY DESIGN In total, 609 patients with locally advanced (cStage II-III) mid to dista...

PURPOSE Molecular classification of breast cancer has been proposed based on gene expression profiles of human tumors. Luminal, basal-like, normal-like, and erbB2+ subgroups were identified and were shown to have different prognoses. The goal of this research was to determine if these different molecular subtypes of breast cancer also respond differently to preoperative chemotherapy. EXPERIME...

Cardiac hypertrophy is a complex and non-homogenous response to various stimuli. In this study, we used high-density oligonucleotide microarray to examine gene expression profiles during physiologic hypertrophy, pathologic hypertrophy, and heart failure in Dahl salt-sensitive rats. There were changes in 404/3160 and 874/3160 genes between physiologic vs. pathologic hypertrophy and the transitio...

Approximately one quarter of patients with breast cancer demonstrate amplification of the human epidermal receptor type 2 (HER2) gene, the expression of which is associated with a relatively poor prognosis independent of other clinical and pathologic variables. Trastuzumab, a humanized recombinant monoclonal antibody specifically directed against the HER2 receptor, has been shown to be biologic...

IntroductionNeoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer. However, response rates and remain suboptimal. We evaluated the efficacy, safety, tolerability of cisplatin plus cabazitaxel.MethodsA phase II single-arm trial was designed to recruit at least 26 evaluable patients. This would give 80% power detect primary endpoint, an objective...

The aim of the study: to increase frequency achieving pathologic complete response and disease-free survival in investigational group patients with locally advanced rectal cancer T3(MRF+)–4N0–2M0 by developing a new strategy for neoadjuvant therapy. Materials methods. In total, 414 were assigned treatment. Control I included 89 who underwent radiotherapy (RT) 52–56 Gy/26–28 fractions concurrent...

Malignant and advanced gastrointestinal stromal tumors (GIST) are currently treated with imatinib mesylate, an inhibitor of KIT and PDGFRA receptor tyrosine kinase. Pathologic evaluation of residual disease is the gold standard in these cases, as clinical and radiologic assessments of treatment response do not always correlate with the pathologic response. Phenotypic and genotypic changes may a...

A) Neoadjuvant therapy Eighty women with breast cancer and a BRCA1 mutation with stage I, II, and III breast cancer between December 2006 and February 2012 were entered into this study. Patients were treated with cisplatin 75 mg/m2 intravenously every three weeks for four cycles. After chemotherapy, patients underwent surgery and were assessed for pathologic response in both the breast and axil...

different studies have reported contradictory results about the effect of osteoporosis on periodontal status. we performed this study to evaluate the periodontal status of menopausal women by methods with enough accuracy and confidence.this study was performed based on the evaluation of bone mineral density using dual energy x-ray absorptiometry in 2010. a total of 60 patients who met the inclu...

background: the pattern of drug abuse in iran has dramatically changed in recent years, turning from the traditional opioids [opium, opium dross, and refined opium dross (shireh)] into drugs with newer forms. the present study is aimed at investigating the frequency of pathological changes in the lungs of bodies with positive postmortem toxicology results for narcotics and psychotropic substanc...