Malaria infection gives rise to host responses which are regulated by both the innate and adaptive immune system as well as by environmental factors. Acquired immunity is both speciesand stage-specific. It is rarely sterile, but rather associated with low-grade parasitemia and episodes of clinical disease throughout life [1, 2]. In endemic areas, children born to immune mothers are protected ag...

Investigations with antisera prepared in rabbits and sheep and active immunity experiments in mice showed that strains of Pasteurella multocida which, according to the haemagglutination test, are serologically related, do not necessarily give rise to cross immunity. Conversely, it was found that serologically unrelated strains may exhibit an appreciable degree of cross protection. The unreliabi...

Effective antiviral protection in multicellular organisms relies on both cell-autonomous and systemic immunity. Systemic immunity mediates the spread of antiviral signals from infection sites to distant uninfected tissues. In arthropods, RNA interference (RNAi) is responsible for antiviral defense. Here, we show that flies have a sophisticated systemic RNAi-based immunity mediated by macrophage...

In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection.

The experimental work herein reported tends to justify our hypothesis recently expressed, that the common failure of antibacterial serums to combat active infections when passively transferred to a normal animal, is due not so much to a lack of suitable or sufficient antibodies as to absence of cell preparation or mobilization in the recipient. In the case of experimental streptococcus empyema ...

A considerable amount of work has been reported in the literature on the effect of x-rays on antibody formation and immunity. With the exception of the reports from our laboratory,5"' the depressing effect of cobalt-60 gamma radiation upon immunity and antibody formation has not been reported. It would seem logical that x-rays and gamma rays should have a similar physiological effect. However, ...

A passive hemagglutination (PHA) test for measles was evaluated in comparison with hemagglutination inhibition (HI) and neutralization (NT) tests. The PHA test determines exclusively the level of antibody directed to the hemagglutinin protein of measles virus. The ratio of PHA to HI titer was 1 to 32 (geometric mean, 6.5) for the first 5 weeks of infection but declined to near unity thereafter....

Pregnant cows were successfully hyperimmunized with all four human rotavirus serotypes, resulting in a 100-fold increase in neutralizing milk antibody titers over those of controls. Milk antibodies were isolated batchwise from 1,000 kg of pooled milk for the first 10 lactation days, yielding 10 kg of freeze-dried milk immunoglobulin concentrate consisting of 50% bovine milk immunoglobulins. Mil...

Litter performance and passive immunity may be affected by dam parity. 1 Summary Preliminary experiments (reported in the 2008 Nebraska Swine Report) suggest that progeny health status may be affected by dam parity. However, the preliminary experiments only included a small population of sows and their progeny. Therefore, the objective of the current experiment was to evaluate litter performanc...

Antibodies have been used for over a century in the prevention and treatment of infectious disease. They are used most commonly for the prevention of measles, hepatitis A, hepatitis B, tetanus, varicella, rabies, and vaccinia. Although their use in the treatment of bacterial infection has largely been supplanted by antibiotics, antibodies remain a critical component of the treatment of diptheri...