psoriasis is an autoimmune and recurrent chronic inflammatory skin disease. about 1-3% of the world wide populations are affected. the characteristic features are hyperprolifration of keratinocytes leading to redness, thickening and scaling of epidermis followed with itching and appearance of the lesions which in most cases bother the patients medically and psychologically. psoriasis is symptom...

BACKGROUND Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression and function of Kv1.3 channels are required for the function of chronically activated memory T cells, which have been shown to be key mediators of autoimmune diseases, including psoriasis. OBJECTIVE The primary objective was to evaluate the safety of repeat doses of dalazatide in adult patients with m...

Photochemotherapy with psoralen plus ultraviolet A(PUVA) and phototherapy with UVB narrow band (UVB-NB) are used in the treatment of psoriasis. Numerous studies have shown that the additional administration of either topical or systemic antipsoriatic agents may effectively increase the efficacy of these therapies. This study aimed to compare through objective data the efficacy of topical tacalc...

Psoriasis is a common inflammatory condition involving the skin, scalp, nails and joints. It significantly increases the risk of cardiovascular events and death in those affected, above Framingham Risk Score (FRS) prediction alone 1 . There is a dose-response element; those with the most severe psoriasis (assessed by the psoriasis area severity index (PASI) score) are at the greatest risk. A UK...

Although skin is the largest organ of the body, there are no standardized reproducible methods for assessing severity of many skin diseases. Due to lack of consensus, methods of assessment and inexistence of precise scoring system, there is no application for vitiligo estimation in real practice. In this paper the author describes VETI score as a new treatment evaluation criteria and severity a...

Introduction: Psoriasis is an immune system-mediated inflammatory disorder characterized by skin inflammation, epidermal hyperplasia, and other comorbidities. Based on medical data from H. Adam Malik hospital in 2011, the proportion of psoriasis vulgaris incidence was 0.81%. It important to assess severity disease. The most frequently used measuring instrument Area Severity Index (PASI) score. ...

BACKGROUND Facial involvement of psoriasis is known to be one of the clinical manifestations that indicate the severity of the psoriasis and thought to be more closely associated with certain distribution. Centrofacial (CF) psoriasis has been suggested to be related with severity of systemic disease while peripherofacial (PF) psoriasis has been thought to have connection with scalp psoriasis. ...

INTRODUCTION Regulatory T cells (Treg) play a central role in the immunopathogenesis of psoriasis. Immunoregulatory T cells (Tregs) are involved in important homeostatic mechanism for maintaining tolerance and preventing autoimmunity, and autoimmune diseases. The aim of this study was to examine the role of Tregs cells in the pathogenesis of psoriasis, and determine the range value for Treg cel...

Tazarotene, the first of new generation receptor selective topical retinoid, currently being investigated and widely used in treatment of mild to moderate psoriasis. The objective of the study is to evaluate the safety and efficacy of topical tazarotene gel 0.1% in comparison with corticosteroid mometasone furoate 0.1% cream in treatment of chronic plaque psoriasis. 50 patients of chronic plaqu...

Background The phase III reSURFACE 1 and 2 (NCT01722331/NCT01729754) trials of the anti-interleukin-23p19 monoclonal antibody tildrakizumab (TIL) for psoriasis treatment are complete. Objectives We present 5-year pooled data from 2. Methods were double-blind, randomized, controlled studies with optional long-term extensions. Adults moderate-to-severe chronic plaque randomized : to TIL 100 mg (T...