نتایج جستجو برای: paroxysmal nocturnal hemoglobinuria
تعداد نتایج: 26047 فیلتر نتایج به سال:
precursors and progenitors to increase production of fetal hemoglobin. J Clin Invest 75: 547-557, 1985 51. Rosa RM, Bierer BE, Thomas R, Jeffrey BS, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH: A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. New Eng J Med303: 1138-1143, 1980 52. Leary M, Abramson N: Induced hyponatremia for sickle-cell crisis. Ne...
A 54-year-old male presented with shortness of breath and was diagnosed with pulmonary emboli. Laboratory studies revealed hemolytic anemia. Flow cytometry showed a prominent white blood cell clone without CD59 in 85% (NV 0-3.0) and red blood cells with 8.5% CD59 absence (NV 0-3.0) confirming a diagnosis of paroxysmal nocturnal hemoglobinuria. Eculizumab was started to decrease the possibility ...
Paroxysmal itching is described in three Japanese women with multiple sclerosis and previously reported cases are discussed. This paroxysmal symptom is rare, but may be the first and only symptom at the onset of multiple sclerosis.
Citation: Rondelli T, Risitano AM, Peffault de Latour R, Sica M, Peruzzi B, Ricci P, Barcellini W, Iori AP, Boschetti C, Valle V, Frémeaux-Bacchi V, De Angioletti M, Socié G, Luzzatto L, and Notaro R. Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria. Haematologica. 2013; 98:xxx doi:10.3324/ha...
In this issue of Blood, Risitano et al demonstrate that small-molecule inhibitors of C3 cleavage prevent complement activation on erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH); the authors demonstrate that these agents reach therapeutic concentrations after subcutaneous injection in nonhuman primates.
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