The parapoxvirus orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host innate and pro-inflammatory responses to infection. Using the ORFV IA82 strain as parental virus, recombinant viruses with individual deletions in genes encoding IMPs chemokine binding protein (CBP; ORFV112), inhibitor of granulocyte-monocyte colony-stimulating factor IL-2 (GIF, ORFV117) interl...

Contagious ecthyma is an infectious skin disease of ruminants caused by the ORF virus (ORFV) that a member genus Parapoxvirus Poxviridae family. In addition to significant effects on lambs and human, ORFVs have been recently shown infect other hosts. The causes economic damages sheep industry, so attempts eliminate it must be taken into.RNA interference (RNAi) evolutionarily conserved mechanism...

The present study describes the generation of a new Orf virus (ORFV) recombinant, D1701-V-RabG, expressing the rabies virus (RABV) glycoprotein that is correctly presented on the surface of infected cells without the need of replication or production of infectious recombinant virus. One single immunization with recombinant ORFV can stimulate high RABV-specific virus-neutralizing antibody (VNA) ...