The purpose of this clinical study was to investigate the influence of concomitant drug therapy with ciprofloxacin and rifampin on the individual pharmacokinetic profile of each agent in elderly patients. Twelve nursing home patients (age, 74 +/- 7 years), colonized with methicillin-resistant Staphylococcus aureus, were randomized to receive 14-day therapy with oral ciprofloxacin (750 mg every ...

This article deals with the kinematics of serial manipulators. The serial manipulators are assumed to be rigid and are modeled using the well-known Denavit-Hartenberg parameters. Two well-known problems in serial manipulator kinematics, namely the direct and inverse problems, are discussed and several examples are presented. The important concept of the workspace of a serial manipulator and the...

In this note, we discuss the derivation of a formula that has been used in the literature in order to compute the number of photons emitted by a hot or dense system during a finite time. Our derivation is based on a variation of the standard operator-based S-matrix approach. The shortcomings of this formula are then emphasized, which leads to a negative conclusion concerning the possibility of ...

To quantify uncertainties in the acoustic field and associated probabilities of the detection and false alarm rate we use concept of a scattering matrix (SM) for acoustic modes. SM describes the process of transformation of modes when propagating through inhomogeneous region. SM depends on the parameters of the inhomogeneities but does not depend on coordinates of the source and receivers. Thus...

This is a preliminary study of the potential relationship between pain and gait parameters in 11 persons with transtibial amputation who underwent gait analysis under both baseline and discomfort walking conditions . Gait analysis included measurement with a VA-Rancho Stride Analyzer of the following gait parameters : velocity, cadence, stride length, gait cycle, and support time . These data w...

Reduced-order modeling techniques are now commonly used to e ciently simulate circuits combined with interconnect, but generating reduced-order models from realistic 3-D structures has received less attention. In this paper we describe a Krylov-subspace based method for deriving reduced-order models directly from the 3-D magnetoquasistatic analysis program FastHenry. This new approach is no mor...

Our laboratory is engaged in an ongoing analysis of a 103-compound data set containing reliable intravenous pharmacokinetic parameters in the rat, dog, monkey, and human, and we have previously reported our findings regarding extrapolation of clearance. In this article, we report on our findings regarding volume of distribution and mean residence time. Various allometric and nonallometric metho...

The basic idea in PRINCIPLES AND PARAMETERS THEORY is to distinguish the invariants of human language (the principles) from the major points of crosslinguistic variation (the parameters). Both principles and parameters are taken to reflect innately determined, biological characteristics of the human brain (see UNIVERSAL GRAMMAR). In the course of normal child development, however, the two diver...

We consider the correlation functions of the tachyon vertex operator of the super Liouville theory coupled to matter fields in the super Coulomb gas formulation, on world sheets with spherical topology. After integrating over the zero mode and assuming that the s parameter takes an integer value, we subsequently continue it to an arbitrary real number and compute the correlators in a closed for...

The first fully automated noise and S-parameter measurement bench is reported for W-band on-wafer characterisation. A calibration procedure is described that allows the receiver reference plane tc, be accurately moved to i:he probe tip.