Efficacy of glucokinase activation on glycemic control is limited to a short-term period. One reason might be related excess glucose signaling by toward ?-cells. In this study, we investigated the effect haploinsufficiency tolerance as well ?-cell function and mass using mouse model type 2 diabetes. Our results showed that in db/db mice with haploinsufficiency, was ameliorated augmented insulin...

In this article, young trans people share their experiences of exhaustion and exhausting temporalities. Drawing on participatory research with aged fourteen to twenty-five in London Scotland, I trace forces implicated the spatial bodily emergence fixity people’s lives sociomaterialities, embodied practices, architectures many everyday spaces, alongside societal hostilities, as a set that often ...