BACKGROUND Whereas paracetamol poisoning is predominantly seen in adolescents and young adults, the majority of paracetamol associated deaths occur in an older population. AIMS The aim of the present study was to evaluate age as a risk factor for fulminant hepatic failure (FHF) and death in a large population of patients with paracetamol poisoning. PATIENTS A total of 746 patients transferr...

BACKGROUND Paracetamol overdose causes severe hepatotoxicity that leads to liver failure in both humans and experimental animals. The present study investigates the protective effect of honey against paracetamol-induced hepatotoxicity in Wistar albino rats. We have used silymarin as a standard reference hepatoprotective drug. METHODS Hepatoprotective activity was assessed by measuring biochem...

A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy, including assisted ventilation for 3 days, led to complete recove...

1 A 24-year-old woman, who was normally fit and well, presented to the emergency department with abdominal pain, nausea and vomiting. She was noted to have scleral jaundice and admitted to taking a paracetamol overdose 24 hours previously. Blood tests were sent. On examination, she appeared drowsy when trying to get a full history. An arterial blood gas revealed pH of 7.38 (7.35–7.45), plasma g...