Introduction PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum, and Acne) is an ultra-rare autosomal dominant, autoinflammatory disease associated to mutations in the PSTPIP1/CD2BP1 gene. The therapeutic approach during recurrences consists of steroids, while no agreement exists on the chronic management. Evidences on the use of biologics are anecdotal and variable results have been repor...

Laboratory of Applied Microbiology, University of Applied Sciences and Arts of Southern 12 Switzerland, Bellinzona, Switzerland; bioMérieux SA, Unit Microbiology, R&D 13 Microbiology, La Balme Les Grottes, France; Department of Dermatology, University 14 Hospital of Zurich, Zurich, Switzerland; Microbiology and Virology Unit, Papa Giovanni 15 XXIII Hospital, Bergamo, Italy; POLE Pharma Consulti...

buerger's disease or thromboangiitis obliterans (tao) seems to be common in ir iran, the present study aimed to evaluate an iranian population with buerger's disease in order to suggest a diagnostic criterion for buerger's disease based on the most frequent findings and to compare it with papa diagnostic criteria. in a cross-sectional study, all patients with resting limb pain, limb ischemic ul...

Early childhood anxiety disorders are common, impairing, and predictive of anxiety and mood disorders later in childhood. Epidemiological studies over the last decade find that the prevalence of impairing anxiety disorders in preschool children ranges from 0.3% to 6.5%. Yet, less than 15% of young children with an impairing anxiety disorder receive a mental health evaluation or treatment. One p...

Nitric oxide is produced during intestinal inflammation and inhibits the epithelial responsiveness to cAMP-dependent secretagogues. The effect is presumably due to inhibition of activation of the CFTR. However, because insertion of CFTR into the epithelial apical membrane is also a cAMP-dependent process, we tested the hypothesis that NO could inhibit cAMP-dependent CFTR trafficking. SCBN intes...

INTRODUCTION In endeavor to suppress the cervical carcinoma there are several possible approaches including measures of primary and secondary prevention. So far effects of these measures on the number of cases and mortality rate of cervical carcinoma were modest. Only exception is organized testing based on cytological exam of the cervical smear - Pap test, which has proven to be highly effecti...

En 2010 tuvo lugar en Roma el Sínodo de Oriente Medio. Este artículo presenta los problemas, conflictos, oportunidades y esperanzas la región las comunidades cristianas Medio, su reflejo Instrumentum Laboris. Se describe desarrollo, resumiendo aportaciones del Papa, Padres Sinodales, Delegados Fraternos otras Iglesias Especiales religiones, sus reflexiones busca una respuesta espiritual, teológ...