this association is mentioned in textbooks by Kreel (1971) and Taybi (1975). Weens and Brown (1945) describe a patient with periosteal thickening and acro-osteolysis without actually mentioning the diagnosis of pachydermoperiostosis. We therefore now wish to record five further patients with this curious condition, four of them showing varying degrees of acro-osteolysis. CASE HISTORIES Case 1. ...

Pachydermoperiostosis (PDP) is a rare hereditary disease characterized by folded coarse skin, hyperostosis, clubbing of fingers and abnormalities in other organs such as gastrointestinal tract. Because of safety parents guides us to familial incidence and penetration of gene in 50% of cases. Diagnosis is based on clinical and radiological findings. Males are more susceptible than females to thi...