نتایج جستجو برای: p2x4 receptor p2x4r
تعداد نتایج: 590537 فیلتر نتایج به سال:
P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening between wild-type and P2X4 knockout mice (21-26 days old). Potentiation evoked by a tetanic presynaptic stimulus (100 Hz, 1 s) paired with postsynaptic depolarization was less in P2X4(-/-) mice than ...
Endothelial purinoceptors play an important role in vascular responses to extracellular adenine nucleotides and hemodynamic forces. Here we report that P2X4 purinoceptor expression in human umbilical vein endothelial cells is transcriptionally downregulated by fluid shear stress. When human umbilical vein endothelial cells were subjected to a laminar shear stress of 15 dyn/cm(2), P2X4 mRNA leve...
Crohn's disease and ulcerative colitis are common forms of inflammatory bowel in people, which result diarrhoea, abdominal pain, fatigue, fever, appetite weight loss.1 In the journal Clinical Translational Medicine Zhong et al. report that loss ATP-gated ion channel P2X4 receptor (P2X4) worsens experimental-induced mice, is associated with increased gastrointestinal inflammation microbiota dysb...
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