BACKGROUND Rs2910164, a Single nucleotide polymorphism (SNP) located in the precursor microRNA sequence of miR-146a, is the only MicroRNA sequence SNP studied in papillary thyroid cancer (PTC). Association studies had been performed in US and UK-Northern European populations, but results were inconsistence. This study evaluated the association between rs2910164 and the risk of PTC as well as be...

Let 1 < p, q < ∞ satisfy 1 p + 1 q = 1. We construct an orthonormal basis {bn} for L(R) such that ∆p(bn) and ∆q(c bn) are both uniformly bounded in n. Here ∆λ(f) ≡ infa∈R `R |x − a||f(x)|dx ́ 1 2 . This generalizes a theorem of Bourgain and is closely related to recent results on the Balian-Low theorem.

BACKGROUND Increased somatostatin receptor (SSTR) expression in patients with undifferentiated nasopharyngeal carcinoma (NPC) has been demonstrated with receptor autoradiography, (111) In-Octreotide scintigraphy, and (68) Ga-DOTA-TOC positron emission tomography (PET)/CT imaging. We sought to compare and correlate the uptake of fluorodeoxyglucose (FDG) and DOTA-NOC in undifferentiated NPC to as...

AIM The goal of the present study was to test the (177)Lu-labelled anti-PSMA monoclonal antibody 3/F11 ((177)Lu-DOTA-3/F11) as a new radioimmunotherapeutic agent in a prostate cancer SCID mouse xenograft model. MATERIALS AND METHODS The mAb 3/F11 was (177)Lu labelled using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) as chelating agent. DOTA-3/F11 was tested for cell bindin...

A promising cancer therapy involves the use of the macrocyclic polyaminoacetate DOTA (1,4,7,10tetraazacyclododecane-1,4,7,10-tetraacetic acid) attached to a tumor-targeting antibody complexed with the â emitter 90Y3+. However, incorporation of the 90Y into the DOTA conjugate is too slow. To identify the origins of this problem, we used ab initio quantum chemistry methods (B3LYP/LACVP* and HF/LA...

Background One mechanism that tumors use to escape immunosurveillance is the overexpression of CD47, which inhibits macrophage mediated phagocytosis pathway. Although blockade CD47-SIRPα axis a promising approach enhance tumor targeted phagocytosis, anti-CD47 monotherapies have not shown meaningful responses in clinical studies solid tumors. Combination cancer therapies aim increase probability...

Blood cyanide (HCN) or plasma thiocyanate (SCN) concentrations, or both, were measured in 30 patients (ages 11 months-72 yr) receiving sodium nitroprusside (SNP) for 12-314 h. Sequential measurements in three of these patients (infused 5, 12 and 13 days) showed that HCN concentrations varied with dose rate, while SCN concentrations increased linearly with increasing SNP dose. The accumulated da...

Accumulating experimental evidence indicates that overexpression of the oncogenic receptor tyrosine kinase, Axl, plays a key role in the tumorigenesis and metastasis of various types of cancer. The objective of this study is to design a novel imaging probe based on the monoclonal antibody, h173, for microPET imaging of Axl expression in human lung cancer. A bifunctional chelator, DOTA, was conj...

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods: 111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radiochemical purity; immunoreactivity). SkBr3 as a HER2/neu positive cell line was used...