BACKGROUND Human African trypanosomiasis is caused by infection with parasites of the Trypanosoma brucei species complex, and threatens over 70 million people in sub-Saharan Africa. Development of new drugs is hampered by the limitations of current rodent models, particularly for stage II infections, which occur once parasites have accessed the CNS. Bioluminescence imaging of pathogens expressi...

Cell-to-cell fusion can be quantified by endowing acceptor and donor cells with latent reporter genes/proteins and activators of these genes/proteins, respectively. One way to accomplish this goal is by using a bipartite lentivirus vector (LV)-based cell fusion assay system in which the cellular fusion partners are transduced with a flippase-activatable Photinus pyralis luciferase (PpLuc) expre...

A relaxed cap-dependence of translation of the mRNA-encoding mammalian heat shock protein Hsp70 may suggest that its 5'-untranslated region (UTR) possesses an internal ribosome entry site (IRES). In this study, this possibility has been tested in transfected cells using plasmids that express dicistronic mRNAs. Using a reporter gene construct, Renilla luciferase/Photinus pyralis luciferase, we s...

We propose a quantization of the Painlevé system of type A (1) l studied by M. Noumi and Y. Yamada [13]. This quantization has the affine Weyl group symmetry of type A (1) l (l ≥ 2) as well as the Lax representation. For even l, the quantized system of type A (1) l can be obtained as the continuous limit of the discrete system constructed from the affine Weyl group symmetry of type A (1) l+1 .

acluster[ pt (reo )(?-dppm) ][reo ],2 [dppm=ph pch ] with oxidaton of [pt re(co) ](?-dppm) ][pf ] is prepred . crystals are triclinic,pl; a= 14.154(4)?, b=14.213(3) ?,c = 20.522(4) ? , a = 78.938(14)?, ?= 75.812(19) ? , ?= 74,957(22) ? ;v = 3828.9(1 5) ? ,z =2 ; eraf-noniu cad4 difhctorneter with mo- k radiation, ? = 0.71073 ? ; r = 0.069, r = 0.077 for 284 parameters and 5414 reflections with ...