Bioassay monitoring of hydroalcoholic extract from the aerial part of Pyconcycla spinosa revealed that it contains components with spasmolytic activity in vitro. In addition, P. spinosa extract at oral dose of 1-5 mg/kg inhibits diarrhoea in animal models. Pharmacological screening of pure compounds isolated from P. spinosa hydroalcoholic extract led to the identification of 3,7,10,14,15-pentaa...

Extract prepared from aerial part of Pycnocycla spinosa is a relaxant of rat ileum contractions. The objective of this research was to study the spasmolytic activity of P. spinosa root extract for comparison with the aerial part extract. Hydroalcoholic extracts were prepared by percolation method. A portion of rat ileum was removed and suspended under 1 g tension in Tyrode's solution at 37 °C a...

OBJECTIVES Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. ...

Parasites of the genus Leishmania are transmitted by sandflies that ingest the parasite in the amastigote stage resident within macrophages, then inoculate the promastigote stage into other hosts. Peganum harmala, or Syrian Rue, has pharmacologically active compounds including several alkaloids with antiprotozoal properties, which are found especially in the seeds and the roots. In this researc...

The gastroprotective effect of the methanol extract of Phyllantus niruri and its main constituent, corilagin, were studied in vivo. The extract (50, 125, or 250 mg/kg, p. o.) inhibited ethanol-induced lesions in rats by 43 % (p < 0.001), 69 % (p < 0.001), and 99 % (p < 0.001), respectively. It also inhibited the formation of indomethacin-induced gastric ulcers in rats by 80 % (p < 0.01), 89 % (...

in order to investigate the effects of peppermint (mentha piperita l.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (ccl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. factors included two levels of peppermint leaf alcoholic extract (0 and 2 ml/kg body weight) and ccl4 (...

BACKGROUND Ginsenosides, the major bioactive compounds in ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. METHODS Male Sprague-Dawley rats were randomly divided into four groups: control, CCl4, CCl4 + 0.5 g/kg Pa...

An experiment (3 × 4 factorial arrangement) was conducted to investigate the interaction between different levels of lactose (60 v. 150 v. 250 g/kg) and seaweed extract (0 v. 1 v. 2 v. 4 g/kg) containing both laminarin and fucoidan derived from Laminaria spp. on growth performance and nutrient digestibility of weanling pigs. In all, 384 piglets (24 days of age, 7.5 kg (s.d. 1 kg) live weight) w...

BACKGROUND The aim of this study was to design and assess the effects of hydroalcoholic extract of Matricaria chamomilla (MC) on preantral follicle culture of mouse ovaries in a three-dimensional culture system. METHODS Isolated preantral follicles were randomly divided into three main groups: the control group containing 10% fetal bovine serum without MC extract (G1), the first experimental ...

Cuscuta australis (C. australis) seed and stem are commonly used as dietary supplements in a maize-meal, "Ogi", by the local population for the management of male and female reproductive dysfunctions. This study, as a part of on-going efforts, therefore, evaluated and compared the effects of Low Protein-energy (LP) and Normal Protein-energy (NP) diets on the sperm morphology and characteristics...