Non-enzymatic glycosylation (glycation) is a spontaneous set of reactions between reducing sugars and free amino groups in proteins or other biomolecules leading to the formation of fluorescent and coloured compounds known as advanced glycation end products (AGEs). AGEs cause structural changes of key proteins in humans, and therefore they are related with a number of physiological processes an...

Tab. 1. NMR-Spektren substituierter Acetanilide a . a In CDC13 , 60 MHz. b Die Zuordnung erfolgte unter der plausiblen Annahme, daß in der eis-Verbindung der Methylteil der CH3CO-Gruppe oberhalb der aromatischen Ringebene zu liegen kommt, ihr NMR-Signal im Vergleich zur fransVerbindung also nach höherem Feld verschoben sein sollte. c Im Falle des cts-2.6-Diisopropyl-acetanilides zeigen die iso-...

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast canc...

Sulphonamides are an important class of heterocyclic compounds which possess wide spectrum of biological properties.The present work deals with the synthesis of some novel Sulphonamide derivatives using acetanilide, chlorsulphonic acid and various aromatic amines. All the synthesized compounds were characterized by IR, 1 H NMR and 13 C NMR Spectroscopy. The compounds were evaluated for their an...

We explored, in rats, the conditions underlying the induction of liver tumors by ./V-hydroxy-./V-2-fluorenylacetamide (N-OH-FAA) in terms of the participation of an ultimate carcinogen in the form of the sulfate ester. Male rats were fed 2 dose levels, i.e., 0.0213%(0.89 mmole/kg) and 0.032%(1.34 mmoles/kg) of N-OH-FAA in the diet, with or without 0.89% (59 mmoles/kg) p-hydroxyacetanilide, and ...