The main aim of this paper is to report the impact of the addition of cellulose nanocrystals (CNC) on the thermal, mechanical, and permeability properties of poly (lactic acid). The thin films were prepared using a modified solvent casting method. The films were fortified with either of two antimicrobial agents: silver (Ag) nanopowder or a peptide. The microstructure, morphology, oxygen and wat...

Sverrisson K, Axelsson J, Rippe A, Asgeirsson D, Rippe B. Acute reactive oxygen species (ROS)-dependent effects of IL-1 , TNF, and IL-6 on the glomerular filtration barrier (GFB) in vivo. Am J Physiol Renal Physiol 309: F800–F806, 2015. First published August 19, 2015; doi:10.1152/ajprenal.00111.2015.—This study was performed to investigate the immediate actions of the proinflammatory cytokines...

PURPOSE The accumulation of advanced glycation end products (AGEs) within the retina in diabetes is associated with a chronic increase in retinal microvascular permeability. Isolated perfused retinas were used to examine the acute effects of AGEs on retinal microvascular permeability. METHODS Retinas were dissected from eyes obtained from male Wistar rats, pinned out flat, and perfused with t...

Available experimental investigations on the effect of the aggregate-paste ‘interfacial transition zone’ (ITZ) on mass transport properties of cement-based materials appear to be ambiguous. Whilst some studies have found a deleterious effect of the ITZ, results from others seem to suggest otherwise. In the present study, we examined the relative influences of ITZ and microcracking on the oxygen...

Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4-/- mice that develop hyperpermeability, but how Robo4 signals remained unclear. Here we show that Robo4 deletion enhances permeability and revascularization in o...

Prolonged anoxia has deleterious effects on islets. Gas-permeable cell culture devices can be used to minimize anoxia during islet culture and especially during shipment when elimination of gas-liquid interfaces is required to prevent the formation of damaging gas bubbles. Gas-permeable bags may have several drawbacks, such as propensity for puncture and contamination, difficult islet retrieval...

Arthropods cope with reduced oxygen and elevated carbon dioxide atmospheres with a reduction in metabolic rate, also called metabolic arrest. The reduction in metabolism lessens the pressure on the organism to initiate anaerobic metabolism, but also leads to a reduction in ATP production. The natural permeability of cellular membranes appears to be important for the survival of the arthropod un...

Oxidative stress plays critical roles in initiation and/or worsening of respiratory disease process. Although reactive oxygen species (ROS) are shown to cause vascular leakage, the mechanisms by which ROS induce an increase in vascular permeability are not clearly understood. In this study, we have used a murine model to evaluate the effect of hydrogen peroxide (H(2)O(2)) to examine roles of RO...