Phosphorylation of respiratory chain components has emerged as a mode of regulation of mitochondrial energy metabolism, but its mechanisms are still largely unexplored. A recently discovered intramitochondrial signalling pathway links CO(2) generated by the Krebs cycle with the respiratory chain, through the action of a mitochondrial soluble adenylyl cyclase (mt-sAC). Cytochrome oxidase (COX), ...

Repeated blood donors manifest clinical, subclinical, and biochemical signs of iron deficiency anemia, have significantly higher erythropoietin and vascular endothelial growth factor (VEGF) concentrations, and decreased tissue oxygen saturation, oxygenated tissue hemoglobin, and regional cerebral oxygen saturation. Erythropoietin and VEGF are potent retinal angiogenic factors which may initiate...

Euglena gracilis (Klebs) cultures were grown under conditions where limitation in supply of manganese limited chlorophyll content much more than growth. Although the initial rates of photosynthetic oxygen evolution were not affected by the level of manganese, photoinhibition in high intensity light was markedly influenced. All cultures showed first order kinetics for photoinhibition, with the h...

A 13 months male child presented with progressive dyspnea of three months and recent cyanosis. Cardio-respiratory examination revealed tachypnea, cyanosis, left parasternal heave and loud P2. Echocardiography revealed thrombus in pulmonary artery and severe pulmonary arterial hypertension. Tests for throbmophilia demonstrated protein S deficiency. Treatment included anticoagulants, sildenafil, ...

Heart failure with preserved ejection fraction (HFpEF) is a significant cardiovascular condition for more than 50% of patients with heart failure. Currently, there is no effective treatment to decrease morbidity and mortality rates associated with HFpEF because of its pathophysiological heterogeneity. Recent evidence shows that deficiency in myocardial bioenergetics is one of the key pathophysi...

BACKGROUND: The ability of plants to adapt oxygen deficiency is associated with the presence various adaptations, many which are mediated by significant changes metabolism. These allow resistant wetland grow even in oxygen-deficient environment.
 AIM: aim study was carry out metabolic profiling leaves species Epilobium palustre and hirsutum, mesophyte angustifolium order identify most char...

Rice seedlings germinating in oxygen-deficient environments do not manifest visual evidence of seminal or adventitious root growth or normal leaf growth, the coleoptile being the only seedling structure to emerge under these environmental conditions. Microscopic evidence, however, shows that mitotic activity occurs in the different tissues comprising the shoots of the seedlings germinating unde...

Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with prematurity and surfactant deficiency. BPD results from the complex interplay between impairments in the premature lung such as surfactant deficiency, perinatal insults such as infection, and damage resulting from supportive care of the infant due to barotrauma or volut...

Anaemia is usually defined in terms of a reduction in the concentration ofhaemoglobin or the number of red cells in the peripheral blood. In the community at large, iron deficiency is by far the most common cause of anaemia. The symptoms of iron deficiency anaemia are said to depend on three factors: the causative disorder, the reduced oxygen-carrying capacity of the blood, and the disturbances...

Oxygen deficiency is commonplace in seeds, and limits both their development and their germination. It is, therefore, of considerable relevance to crop production. While the underlying physiological basis of seed hypoxia has been known for some time, the lack of any experimental means of measuring the global or localized oxygen concentration within the seed has hampered further progress in this...