OBJECTIVES The objective of this study was to examine Klebsiella oxytoca clonal and phylogenetic diversity, based on an international collection of carriage isolates non-susceptible to expanded-spectrum cephalosporins (ESCs). METHODS The study material comprised 68 rectal carriage K. oxytoca isolates non-susceptible to ESCs recovered in 2008-11 from patients in 14 hospitals across Europe and ...

OBJECTIVES The lateral prefrontal cortex (LPFC) plays a central role in working memory (WM). In the present study, we employed quantitative, near-infrared time-resolved spectroscopy (TRS) to evaluate the relation between LPFC activity during WM and the task performance in 19 healthy, middle-aged, female subjects (mean age of 46·8±2·1 years). METHODS Concentration changes of oxyhemoglobin (ox...

The three title compounds form part of a set of important precursor dissacharides which lead to novel therapeutics, in particular for Alzheimer's disease. All three crystallize as poorly diffracting crystals with one independent mol-ecule in the asymmetric unit. Two of them are isostructural: 4-meth-oxy-phenyl 4-O-[6-O-acetyl-2-azido-3-O-benzyl-2-de-oxy-4-O-(9-fluor-en-yl-methyl-oxycarbon-yl)-α...

THE TITLE COMPOUND (SYSTEMATIC NAME 5,7-dihydr-oxy-3,6,8-trimeth-oxy-4H-chromen-4-one), C(18)H(16)O(7), is a flavone that was isolated from Ainsliaea henryi. There are two mol-ecules in the asymmetric unit, one of which has a disordered meth-oxy group [occupancy ratio 0.681 (9):0.319 (9)]. Both mol-ecules have an intra-molecular O-H⋯O hydrogen bond. In the crystal, mol-ecules are linked into O-...

The pyranosyl ring in the title compound, C(31)H(34)Cl(2)O(7), adopts a twist-boat conformation. The 4-meth-oxy-benzyl groups are located in equatorial positions with the meth-oxy groups nearly coplanar with their respective rings [dihedral angles of 0.2 (3) and 9.4 (2)°]. The aromatic rings adopt orientations enabling them to participate in C-H⋯π inter-actions with neighboring meth-oxy groups....

In the title mol-ecule, C(10)H(11)NO(2), the benzene ring forms dihedral angles of 33.15 (2) and 6.20 (2)° with the mean planes of the amide and propen-oxy groups, respectively. The amide -NH(2) group is oriented toward the propen-oxy substituent and forms a weak intra-molecular N-H⋯O hydrogen bond to the propen-oxy O atom. The conformation of the propen-oxy group at the Csp(2)-Csp(3) and Csp(3...

THE TITLE COMPOUND, [SYSTEMATIC NAME: 5a-acet-oxy-methyl-3-isopropyl-8-methyl-1,2,3,3a,4,5,5a,6,7,10,10a,10b-dodeca-hydro-7,10-endo-epidi-oxy-cyclo-hepta-[e]indene-3a-carb-oxy-lic acid], C(22)H(32)O(6) (I), is closely related to methyl 5a-acet-oxy-methyl-3-isopropyl-8-methyl-1,2,3,3a,4,5,5a,6,7,10,10a,10b-dodeca-hydro-7,10-endo-epidi-oxy-cyclo-hepta-[e]indene-3a-carboxyl-ate, (II) [Brito et al....