Sickle cell disease (SCD) is a monogenetic disorder caused by single amino acid change in the beta globin gene. This mutation facilitates the production of unstable sickle hemoglobin (Hb S) which upon deoxygenation forms higher order aggregates which cause erythrocyte rigidity. These rigid cells block the microvasculature resulting in vaso-occlusion, tissue ischemia, organ damage, pain and deat...

BackgroundOxidative stress has been implicated in various pathological conditions but the available studies concerning oxidant stress in hypothyroidism are controversial and inconclusive. While some authors suggest that tissues may be protected from oxidant damage because of a hypometabolic state in hypothyroidism, others report an increased oxidative stress in hypothyroidism. Aims and objectiv...

seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. despite the diversity in quality and quantity of the mediterranean tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...

results a significant higher serum pab value was observed in shift working and daytime nurses (152.28 ± 43.64 hk) in comparison to the control group (63.64 ± 34.41 hk index), p value = 0.001. in day time nurses, also serum pab between male (119.09 ± 47.14 hk) and female (162.53 ± 37.02 hk) in nursing workers was significant, p value = 0.005. in the night shift working nurses, there was also a s...

objective: crocin, the carotenoid isolated from saffron, has numerous medicinal properties which include anticancer and antioxidant activities. some antioxidants, such as carotenoids, can act as pro-oxidants at higher dosages and therefore induce tissue damage. in this situation antioxidant defense systems in the liver activate to prevent tissue damage. this study investigates the possible toxi...

objectives: iron chelators, such as maltol and kojic acid, have antioxidant and anti-inflammatory properties. they may have beneficial effects on inflammatory bowel disease (ibd) because iron can develop and aggravate inflammation in ibd. in the present study, the effect of selected iron chelators and anti-oxidants were evaluated on a model of trinitrobenzene sulfonic acid (tnbs)-induced coliti...

Acne is the inflammatory response of increased levels hormones. Generally seen on face as well back, characterized by pimples, black heads, white heads and pustules. It may get severe if remains untreated. directly correlates with psychological conditions such low self confidence to socialize, esteem, etc. most common in citizens thriving central peninsular regions India especially teenagers. S...

The effects of hyperbaric oxygen (HBO) therapy on oxidant/antioxidant metabolism are controversial and its effects on hepatic regeneration are not known. In this study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight Spraggue-Dawley rats and t...

Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the 'oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity to cellular hypoxia, the HIF asparaginyl hydroxylase--known as FIH, factor inhibiting HIF--is strikingl...