نتایج جستجو برای: oxazolidinone antibiotic

تعداد نتایج: 82349  

2012
Toshiki Nokami Akito Shibuya Yoshihiro Saigusa Shino Manabe Yukishige Ito Jun-ichi Yoshida

Glycosyl triflates with a 2,3-oxazolidinone protecting group were generated from thioglycosides by low-temperature electrochemical oxidation. The glycosyl triflates reacted with alcohols to give the corresponding glycosides β-selectively at low temperatures. However, α-selectivity was observed in the absence of base at elevated reaction temperatures. In situ generated triflic acid promotes the ...

Journal: :Organic letters 2012
Sebastian T Le Quement Thomas Flagstad Remi J T Mikkelsen Mette R Hansen Michael C Givskov Thomas E Nielsen

An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.

Journal: :Compounds 2021

The SPME (Solid Phase Microextraction) analysis of the scent H. hircinum showed presence elemicin in a relevant amount eugenol. sample adriaticum collected Abruzzo 4-amino-5-(4-morpholinylmethyl)-2-oxazolidinone, ?-ocimene, decyl decanoate, and 9-tricosene as main components. at Marsico Nuovo has an aroma where component was pentadecyl hexanoate, 9-tricosene, methyleugenol, tetradecane, pentade...

Journal: :Bioscience, biotechnology, and biochemistry 1998
Y Nakamura M Hirata E Kuwano E Taniguchi

(+)-(2R,3R)-7-Formyl-6-methoxy-2-methoxymethyl-3- (3,4-methylenedioxyphenyl)-2,3-dihydro-1,4-benzodioxin (2), a key building block for the total synthesis of haedoxan A, was synthesized from (4R)-4-(phenylmethyl)-2-oxazolidinone (3) in ten steps with a 12% overall yield.

Journal: :Antimicrobial agents and chemotherapy 2009
Corinna Kehrenberg Christiane Cuny Birgit Strommenger Stefan Schwarz Wolfgang Witte

Methicillin-resistant Staphylococcus aureus clonal lineage ST398 and methicillin-susceptible lineage ST9 strains have their main reservoir in swine but can colonize and cause infections in humans. The phenicol/lincosamide/oxazolidinone/pleuromutilin/streptogramin A multidrug resistance gene cfr was detected in isolates of both clonal lineages, rendering a spread to humans with exposure to swine...

2016
Jan Tatarkiewicz Anna Staniszewska Magdalena Bujalska-Zadrożny

Vancomycin has been a predominant treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections for decades. However, growing reservations about its efficacy led to an urgent need for new antibiotics effective against MRSA and other drug-resistant Staphylococcus aureus strains. This review covers three new anti-MRSA antibiotics that have been recently approved by the FDA: dalbavan...

2012
Richard R Watkins Tracy L Lemonovich Thomas M File

Methicillin-resistant Staphylococcus aureus (MRSA), including community-associated and hospital-associated strains, is a major cause of human morbidity and mortality. Treatment options have become limited due to the emergence of MRSA strains with decreased sensitivity to vancomycin, which has long been the first-line therapy for serious infections. This has prompted the search for novel antibio...

2016
Wenqing Hu Bing Shi Lihui Liu Shengke He Liping Ye DengMei Tian Yongqing Zhang

Linezolid (LZD), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. LZD can induce thrombocytopenia, anemia and leukocytopenia. Currently, reports on pure red cell aplasia (PRCA) cases induced by LZD are relatively rare (4-7). In this paper, we reported a patient with PRCA twice induced by LZD. A 37-year-old man was diagnosed with myelody...

Journal: :The Journal of antimicrobial chemotherapy 2005
Stefanie Swoboda Stefan Fritz Marcus E Martignoni Rita A Feldhues Torsten Hoppe-Tichy Markus W Buchler Heinrich K Geiss

OBJECTIVES Linezolid is an oxazolidinone antibiotic used in the treatment of infections caused by vancomycin-resistant enterococci. Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. PATIENT AND METHODS We present clinical details and susceptibility data from multiple Enterococcus faecium strains isolated from a liver transplant patient over 13 mon...

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