Primary hyperoxaluria is characterized during life by a continuous urinary oxalate excretion level of about 100-400 mg. (expressed as (COOH)2.2H20) per 24 hours as opposed to the normal value of less than 45 mg. per 24 hours. Patients with this disease usually present in early childhood with multiple bilateral renal or ureteric calculi which increase rapidly in size and are composed wholly or p...

Secondary oxalosis causing acute kidney injury (AKI) has been widely reported in native kidneys but its occurrence in allograft kidneys is relatively uncommon. We present three patients with acute kidney allograft dysfunction secondary to tubular oxalate microcrystal deposits confirmed on allograft biopsy in the setting of acute gastrointestinal dysfunction. These three patients presented with ...

Abstract Background and Aims Primary Hyperoxaluria type 3 (PH3) is said to be the less problematic form of PH with low risk chronic kidney disease (CKD) end stage renal disease. However, a recent OxalEurope registry evaluation reported both urine plasma oxalate levels in comparable range as PH1 PH2 patients. In addition, PH3 patients remain symptomatic recurrent stones, even adulthood, 24% 95 e...

An 11-year-old boy was found to have primary hyperoxaluria type I (urine oxalate 828mg/l, N 140–420mg/l). His mother had kidney stones and the parents were second degree relatives. After 18 months of dialysis, femoral neck fracture occurred, which was assumed to be related to renal osteodystrophy. During the surgical procedure to fix the fracture site internally, biopsies were taken which showe...